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Intercellular adhesion molecule-1 (ICAM-1) expression in the islets of the non-obese diabetic and low-dose streptozocin-treated mouse

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The expression of intercellular adhesion molecule-1 (ICAM-1) was studied in 8-week-old non-obese diabetic (NOD) mice and low-dose streptozocin-treated (LDS) mice. ICAM-1 expression in NOD mice was observed at the islet periphery, corresponding to the perislet venular network, within the islet and on scattered elements along septa of the exocrine portion of the pancreas. Image analysis demonstrated that LDS-treated animals had less ICAM-1 immunoreactivity within and around the islets compared to NOD mice. At the ultrastructural level the peri-islet vessels were found to be filled with mononuclear elements. Moreover, endothelial cells showed signs of activation, and margination of monocytes and polymorphonuclear leukocytes was observed.

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  1. Charlton B, Bacelj A, Mandel TE (1988) Administration of silica particles or anti-Lyt2 antibody prevents B-cell destruction in NOD mice given cyclophosphamide. Diabetes 37:930–935

  2. Hänninen A, Jalkanen S, Salmi M, Toikkanen S, Nilolakros G, Simell O (1992) Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 90:1901–1910

  3. Ihm S-H, Yoon J-W (1990) Studies on autoimmunity for initiation of B-cell destruction. VI. Macrophages are essential for development of B-cell specific cytotoxic effectors and insulitis in NOD mice. Diabetes 39:1273–1278

  4. Lee K-U, Amano K, Yoon J-W (1988) Evidence for initial involvement of macrophages in development of insulitis in NOD mice. Diabetes 37:989–991

  5. Maclaren N, Lafferty K (1993) The 12th International Immunology and Diabetes Workshop, Orlando, Florida. Diabetes 42:1099–1104

  6. Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813–819

  7. Papaccio G, Chieffi Baccari G (1992) Alterations of islet microvasculature in mice treated with low-dose streptozocin. Histochemistry 97:371–374

  8. Papaccio G, Chieffi Baccari G, Mezzogiorno V, Esposito V (1990) Capillary area in early low-dose streptozocin-treated mice. Histochemistry 95:19–21

  9. Papaccio G, Linn T, Federlin K, Volkmann A, Esposito V, Mezzogiorno V (1991) Further morphological and biochemical observations on early low dose streptozocin diabetes in mice. Pancreas 6:659–667

  10. Papaccio G, Chieffi Baccari G, Mezzogiorno V, Esposito V (1993a) Extraislet infiltration in NOD mouse pancreas: observations after immunomodulation. Pancreas 8:459–464

  11. Papaccio G, Linn T, Chieffi Baccari G (1993b) Morphological observations on pancreatic islet blood vessels in low dose streptozocin treated mice. J Anat 182:45–53

  12. Pober JS (1988) Cytokine-mediated activation of vascular endothelium. Am J Pathol 133:426–433

  13. Pober JS, Cotran RS (1990) The role of endothelial cells in inflammation. Transplantation 50:537–544

  14. Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA Jr (1987) Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol 138:3319–3324

  15. Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434

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Correspondence to G. Papaccio.

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Linn, T., Strate, C., Federlin, K. et al. Intercellular adhesion molecule-1 (ICAM-1) expression in the islets of the non-obese diabetic and low-dose streptozocin-treated mouse. Histochemistry 102, 317–321 (1994). https://doi.org/10.1007/BF00269169

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  • Public Health
  • Endothelial Cell
  • Image Analysis
  • Intercellular Adhesion
  • Polymorphonuclear Leukocyte