Molecular and General Genetics MGG

, Volume 109, Issue 4, pp 285–291 | Cite as

Analysis of a case of mutagen specificity inNeurospora crassa

III. Fractionated treatment with diepoxybutane (DEB)
  • C. Auerbach
  • D. Ramsay


Weak doses of DEB given before or after a moderately high dose act as “booster” for the production of adenine-reversions. Fractionation of a moderate or high dose into a succession of weak ones yields a dose-effect curve that lies above the linear curve expected for additivity of the fractions but below that found after continuous exposure. The results lend support to the view that DEB, in addition to producing potential adenine-reversions in DNA, promotes their realization by its effect on some cellular process or processes, and that this is the cause of the steep dose-response to continuous exposure.


Fractionation Cellular Process Continuous Exposure Mutagen Specificity Linear Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Auerbach, C., Ramsay, D.: Analysis of a case of mutagen specificity inNeurospora crassa I. Dose-response curves. Molec. Gen. Genetics103, 72–104 (1968).CrossRefGoogle Scholar
  2. —: II. Interaction between treatments with diepoxybutane (DEB) and ultraviolet light. Molec. Gen. Genetics109, 1–14 (1970).CrossRefGoogle Scholar
  3. Kilbey, B. J.: The interaction between diepoxybutane and ultraviolet light in yeast. II. Experiments with UV-sensitive and resistant strains. Mutation Res. (in press).Google Scholar
  4. Kølmark, G., Auerbach, C.: Mutagenic after-effect inNeurospora treated with DEB. Microbial Gen Bull.17, 24–25 (1960).Google Scholar
  5. —, Kilbey, B. J.: An investigation into the mutagenic after-effect of butadiene epoxide usingNeurospora crassa. Z. Vererbungsl.93, 356–365 (1962).Google Scholar
  6. —: Kinetic studies of mutations induced by epoxides inNeurospora crassa. Molec. Genetics101, 89–98 (1963).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • C. Auerbach
    • 1
  • D. Ramsay
    • 1
  1. 1.Institute of Animal GeneticsEdinburgh

Personalised recommendations