Molecular and General Genetics MGG

, Volume 133, Issue 3, pp 237–247 | Cite as

Genetic instability in Drosophila melanogaster

Evidence for insertion mutations
  • B. Rasmuson
  • M. M. Green
  • Britt-Marie Karlsson


An X chromosome in Drosophila melanogaster is described which is mutationally unstable. Mutational events were identified through phenotypic changes associated with a tandem duplication of the X chromosome in which the white locus is present in duplicate. The left segment of the tandem duplication was marked with the mutant wsp, the right segment with mutant w17G. Some of the phenotypic changes were identified as deletions involving the w17G marked segment of the duplication. Other phenotypic changes involved the left segment in which phenotypically wsp mutated to w. Experimental evidence is presented which attributes these latter mutations to insertions of “foreign” DNA into the w locus equivalent to the insertion mutations of E. coli.


Experimental Evidence Mutational Event Phenotypic Change Tandem Duplication Genetic Instability 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • B. Rasmuson
    • 1
  • M. M. Green
    • 2
  • Britt-Marie Karlsson
    • 1
  1. 1.Department of GeneticsUniversity of UmeåSweden
  2. 2.Department of GeneticsUniversity of CaliforniaDavisU.S.A.

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