Advertisement

Molecular and General Genetics MGG

, Volume 133, Issue 3, pp 237–247 | Cite as

Genetic instability in Drosophila melanogaster

Evidence for insertion mutations
  • B. Rasmuson
  • M. M. Green
  • Britt-Marie Karlsson
Article

Summary

An X chromosome in Drosophila melanogaster is described which is mutationally unstable. Mutational events were identified through phenotypic changes associated with a tandem duplication of the X chromosome in which the white locus is present in duplicate. The left segment of the tandem duplication was marked with the mutant wsp, the right segment with mutant w17G. Some of the phenotypic changes were identified as deletions involving the w17G marked segment of the duplication. Other phenotypic changes involved the left segment in which phenotypically wsp mutated to w. Experimental evidence is presented which attributes these latter mutations to insertions of “foreign” DNA into the w locus equivalent to the insertion mutations of E. coli.

Keywords

Experimental Evidence Mutational Event Phenotypic Change Tandem Duplication Genetic Instability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bowman, J. T.: Spontaneous reversion of the white-ivory mutant of Drosophila melanogaster. Genetics 52, 1069 (1965)Google Scholar
  2. Bowman, J. T., Green, M. M.: X-ray induced reversion of the white-ivory mutant of Drosophila melanogaster. Genetics 37, 7 (1966)Google Scholar
  3. Green, M. M.: Putative non-reciprocal crossing over in Drosophila melanogaster. Z. Vererbungsl. 90, 375 (1959)Google Scholar
  4. Green, M. M.: The genetics of a mutable gene at the white locus of Drosophila melanogaster. Genetics 56, 467 (1967)Google Scholar
  5. Green, M. M.: Some genetic properties of intrachromosomal recombination. Molec. gen. Genet. 103, 209 (1968)Google Scholar
  6. Green, M. M.: Mapping a Drosophila melanogaster “controlling element” by interallelic crossing over. Genetics 61, 423 (1969)Google Scholar
  7. Lefevre, G., Green, M. M.: Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster chromosome. Chromosoma (Berl.) 36, 391 (1972)Google Scholar
  8. Lewis, E. B.: Germinal and somatic reversion of the ivory mutant in Drosophila melanogaster. (Abst.) Genetics 44, 522 (1959)Google Scholar
  9. Lindsley, D. L., Grell, E. H.: Genetic variations in Drosophila melanogaster. Carnegie Inst. Wash. Publ. 627 (1968)Google Scholar
  10. McClintock, B.: The origin and behavior of mutable loci in maize. Proc. nat. Acad. Sci. (Wash.) 36, 344 (1950)Google Scholar
  11. McClintock, B.: Chromosome organization and genetic expression. Cold Spr. Harb. Symp. quant. Biol. 16, 13 (1951)Google Scholar
  12. Peterson, H. M., Laughnan, J. R.: Intrachromosomal exchange at the Bar locus in Drosophila. Proc. nat. Acad. Sci. (Wash.) 50, 126 (1963)Google Scholar
  13. Peterson, P. A.: Controlling elements and mutable loci in maize: their relationship to bacterial episomes. Genetica 41, 33 (1970)Google Scholar
  14. Rasmuson, B.: An intragenic duplication in Drosophila melanogaster and its significance for gene function. Hereditas (Lund.) 48, 612 (1962)Google Scholar
  15. Starlinger, P., Saedler, H.: Insertion mutations in microorganisms. Biochemie 54, 177 (1972)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • B. Rasmuson
    • 1
  • M. M. Green
    • 2
  • Britt-Marie Karlsson
    • 1
  1. 1.Department of GeneticsUniversity of UmeåSweden
  2. 2.Department of GeneticsUniversity of CaliforniaDavisU.S.A.

Personalised recommendations