Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Le controle du développement des bactériophages tempérés

IV. Action spécifique du produit N au niveau d'une barrière de transcription

Control of development in temperate bacteriophages

IV. Specific action of N product at a transcription stop signal

  • 26 Accesses

  • 14 Citations

Summary

Viable recombinants having the (N-im) region of ϕ80 and the (P-R) region of λ can be isolated from crosses between ϕ80 and λ, but only if the λ parent carries a byp mutation.

It is suggested that the transcriptional terminator t R 2located between genes P and Q can be bypassed only in the presence of Nλ product and not in the presence of N ϕ80 product.

This is a preview of subscription content, log in to check access.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Bibliographie

  1. Appleyard, R.: Segregation of lysogenicity during bacterial recombination in E. coli K12. Genetics 39, 429 (1954).

  2. Beckman, J. S., Daniel, V., Tichaner, Y., Littauer, V. Z.: Binding of the termination factor ϱ to DNA. Biochem. biophys. Res. Commun. 43, 806 (1971).

  3. Butler, B., Echols, H.: Regulation of bacteriophage λ development by gene N; Properties of a mutation that bypasses N control of late proteins synthesis. Virology 40, 212 (1970).

  4. Campbell, A.: Sensitive mutants of bacteriophage λ. Virology 14, 22 (1961).

  5. Couturier, M., Dambly, C.: Activation séquentielle des fonctions tardives chez les bacteriophages tempérés. C.R. Acad. Sci. (Paris) 270, 428 (1970).

  6. Dambly, C., Couturier, M., Thomas, R.: Control of development in temperate bacteriophages. II. Control of lysozyme synthesis. J. molec. Biol. 32, 67 (1968).

  7. Fiendt, M., Hradecna, Z., Lozerjn, H., Szybalski, W.: Electron micrographic mapping of deletions, substitions, inversions and homologies in the λ and ϕ80 genomes. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  8. Franklin, N.: The N. operon of λ: extent and regulation as observed in fusions to the tryptophan operon of E. coli. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  9. Georgopoulos, C., Herskowitz, I.: Escherichia coli mutants blocked in λ DNA synthesis. The bacteriophage λ, A.D. Hershey, ed. Cold Spring Harbor: 1971.

  10. Ghysen, A., Pironio, M.: Relationship between the N function of bacteriophage λ and host RNA polymerase. Sous presse J. molec. Biol.

  11. Gottesman, M., Yarmolinsky, M.: Integration-negative mutants of bacteriophage. J. molec. Biol. 31, 487 (1968).

  12. Hopkins, N.: Bypassing a positive regulator: isolation of a λ mutant that does not require N product to grow. Virology 40, 223–229 (1970).

  13. Luzzati, D.: Regulation of λ exonuclease synthesis: Role of the N gene product and λ repressor. J. molec. Biol. 49, 515 (1970).

  14. Pereira Da Silva, L., Jacob, F.: Etude génétique d'une mutation modifiant la sensibilité à l'immunité chez le bacteriophage λ. Ann. Inst. Pasteur 115, 145 (1968).

  15. Roberts, J.: Termination factor for RNA synthesis. Nature (Lond.) 224, 1168 (1969).

  16. —: The ϱ factor: Termination and anti-termination in λ. Cold Spr. Harb. Symp. quant. Biol. 35, 121 (1970).

  17. Sato, K.: Genetic map of bacteriophage ϕ80: Genes of the right arm. Virology 40, 1067 (1970).

  18. —, Nishimune, Y., Sato, M., Numich, R., Matsushiro, A., Inokuchi, H., Ozeki, H.: Suppressor-sensitive mutants of coliphage ϕ80. Virology 34, 1637 (1968).

  19. Szpirer, J., Brachet, P.: Relations physiologiques entre les phages tempérés λ et ϕ80. Molec. gen. Genet. 108, 78 (1970).

  20. —, Thomas, R., Radding, C.: Hybrids of bacteriophages λ and ϕ80: a study of non vegetative functions. Viorology 37, 585 (1969).

  21. Thomas, R.: Control of development in temperate bacteriophages. I. Induction of prophages genes following hetero-immune super-infection. J. molec. Biol. 22, 79–95 (1966).

  22. —: Control of development in temperate bacteriophages. II. Which prophage genes are and which are not trans-activable in the presence of immunity. J. molec. Biol. 49, 393–404 (1970).

  23. —: Regulation of gene expression in bacteriophage λ. Curr. Top. Microbiol. 56, 13–42 (1971).

Download references

Author information

Additional information

Les numéros I, II et III de cette série sont respectivement Thomas, 1966. Dambly, Couturier et Thomas, 1968. Thomas, 1970.

Chargé de Recherches au Fonds National de la Recherche Scientifique Belge.

Communicated by W. Arber

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Szpirer, J. Le controle du développement des bactériophages tempérés. Molec. Gen. Genet. 114, 297–304 (1972). https://doi.org/10.1007/BF00267498

Download citation