The effect of i.m. Ketamine HCl (150 mg/Kg) and topically applied 2% nitroglycerine cream on the survival of experimental flaps in rats was evaluated for eight days. Ketamine HCl alone, when injected every 6 h for seven days following surgery, significantly improved flap survival. Topically applied 2% nitroglycerine, significantly hindered flap survival. Ketamine HCl with 2% nitroglycerine cream did not show any positive synergistic effect, but adversely affected flap survival. Ketamine HCl, when administered every 12 h during seven days post-operatively, did not affect flap survival. It is suggested that the salutary effect of Ketamine HCl is mediated by producing marked vasodilation of the dermal vessels, as well as increasing blood pressure, which ultimately enhances blood flow to the flap.
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Kaufman, T., Angel, M.F., Levin, M. et al. The effect of i.m. ketamine HCl and 2% topical nitroglycerine cream on the survival of experimental flaps. Chir Plastica 8, 45–49 (1984). https://doi.org/10.1007/BF00266859
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