Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Experimental model of haemophilic arthropathy with high pressure haemarthrosis


An experimental model of haemophilic arthropathy was developed in 12 growing dogs by anastomosing the popliteal artery to the joint cavity of the knee to produce haemarthrosis under considerable pressure. The dogs were sacrificed at intervals of one to eight weeks and the morphological and radiological changes found in the specimens mimicked those occurring in haemophilic arthropathy. In some of the animals total destruction of the articular cartilage and subchondral bone occurred. The significance of a high pressure haemarthrosis is discussed in relation to the development of changes found in haemophilic arthropathy.


Un modèle expérimental d'arthropathie hémophilique a été réalisé chez 12 jeunes chiens en anastomosant l'artère poplitée à l'articulation du genou de façon à produire une hémarthrose sous une très importante tension. Les chiens ont été sacrifiés à des intervalles de une à huit semaines. Les modifications macroscopiques et radiologiques découvertes étaient tout à fait comparables à celles que l'on observe dans les arthropathies hémophiliques. Quelques animaux présentaient même une destruction complète du cartilage articulaire et de l'os sous-chondral. L'auteur discute la signification d'une hémarthrose sous forte tension et sa relation avec la survenue des altérations caractéristiques de l'arthropathie hémophilique.

This is a preview of subscription content, log in to check access.


  1. 1.

    Baeza, V., Esquerdo, J.: Hemartrosis experimental. Rev. Esp. Cir. Osteo. 11 (1970)

  2. 2.

    De Palma, A. F.: Haemophilic arthropathy. Clin. Orthop. 52, 145 (1967)

  3. 3.

    Duthie, R. B., Matthews, J. M., Rizza, C. R., Steel, W. M.: The management of musculo-skeletal problems in the Haemophilias, 1st edn. Oxford: Blackwell Scientific Publications 1972

  4. 4.

    Gomar, F.: Patologia quirúrgica osteoarticular, 1st edn. Valencia: Editorial Saber 1973

  5. 5.

    Gomar-Sancho, F.: Artropatia hemofílica. El hemartros reiterado como modelo experimental de la misma. Rev. Esp. Cir. Ost. 12, 353 (1977)

  6. 6.

    Guicciardi, E., Litle, K.: Some observations on the effects of blood and a fibrinolitic enzymes on articular cartilage in the rabbit. J. Bone Joint Surg. [Br.] 49, 342 (1967)

  7. 7.

    Hoaglund, F. T.: Experimental haemarthrosis. The response of canine knees to injections of autologous blood. J. Bone Joint Surg. [Am.] 49, 285–298 (1967)

  8. 8.

    Key, J. A.: The reactions of joints to mild irritants. J. Bone Joint Surg. 11, 233 (1929)

  9. 9.

    Rodnan, G. P.: Some observation on experimental haemarthrosis and pathogenesis of haemophilic arthritis. Lab. Invest. 8, 1278 (1959)

  10. 10.

    Roy, S.: Ultrastructure of articular cartilage in experimental haemarthrosis. Arch. Pathol. 86, 69 (1968)

  11. 11.

    Smille, I. S.: Traumatic synovitis and haemarthrosis in injuries of knee joint, 3rd. edn. London: Livingstone 1962

  12. 12.

    Soeur, R.: The synovial membrane of the knee in pathological conditions. J. Bone Joint Surg. [Am.] 31, 317 (1949)

  13. 13.

    Sokoloff, L.: Biochemical and physiological aspects of degenerative joint diseases with special reference to haemophilic arthropathy. Ann. Acad. Sci. New York 240, 285 (1975)

  14. 14.

    Storti, E., Ascari, A., Molinart, E., Gamba, G.: Artropatia emofílica. LVII Congresso della Societá Italiana di Ortopedia e Traumatologia. Bologna Ottobre 1972

  15. 15.

    Trueta, J.: Studies of the development and decay of the human frame. 1st edn. London: Heinemann Medical Books Ltd. 1968

  16. 16.

    Wolf, C. R., Mankin, H. J.: The effect of experimental haemarthrosis on articular cartilage of rabbit knee joints. J. Bone Joint Surg. [Am.] 47, 1203 (1965)

  17. 17.

    Young, J. M., Hudaced, M. D.: Experimental production of pigmente villonodular synovitis in dogs. J. Pathol. [Am.] 30, 799 (1954)

Download references

Author information

Correspondence to F. Gomar Sancho.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sancho, F.G. Experimental model of haemophilic arthropathy with high pressure haemarthrosis. International Orthopaedics 4, 57–62 (1980).

Download citation

Key words

  • Haemophilic arthropathy
  • Experimental model
  • Pathology