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Experimental model of haemophilic arthropathy with high pressure haemarthrosis

Summary

An experimental model of haemophilic arthropathy was developed in 12 growing dogs by anastomosing the popliteal artery to the joint cavity of the knee to produce haemarthrosis under considerable pressure. The dogs were sacrificed at intervals of one to eight weeks and the morphological and radiological changes found in the specimens mimicked those occurring in haemophilic arthropathy. In some of the animals total destruction of the articular cartilage and subchondral bone occurred. The significance of a high pressure haemarthrosis is discussed in relation to the development of changes found in haemophilic arthropathy.

Résumé

Un modèle expérimental d'arthropathie hémophilique a été réalisé chez 12 jeunes chiens en anastomosant l'artère poplitée à l'articulation du genou de façon à produire une hémarthrose sous une très importante tension. Les chiens ont été sacrifiés à des intervalles de une à huit semaines. Les modifications macroscopiques et radiologiques découvertes étaient tout à fait comparables à celles que l'on observe dans les arthropathies hémophiliques. Quelques animaux présentaient même une destruction complète du cartilage articulaire et de l'os sous-chondral. L'auteur discute la signification d'une hémarthrose sous forte tension et sa relation avec la survenue des altérations caractéristiques de l'arthropathie hémophilique.

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Correspondence to F. Gomar Sancho.

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Sancho, F.G. Experimental model of haemophilic arthropathy with high pressure haemarthrosis. International Orthopaedics 4, 57–62 (1980). https://doi.org/10.1007/BF00266604

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Key words

  • Haemophilic arthropathy
  • Experimental model
  • Pathology