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Bone levels of cephradine and cefuroxime after intravenous administration in patients undergoing total hip replacement

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Summary

A randomised, comparative study is reported of single intravenous doses of cephradine 2 g or cefuroxime 1.5 g given as prophylactic cover for total hip replacements in 40 patients. The serum and bone levels of cephalosporin achieved were higher in the cephradine treated group in proportion to the higher dose employed. Both agents provided adequate bone levels on average, cephradine 25.34 mcg/g, cefuroxime 17.39 mcg/g, although bone penetration was more variable with cefuroxime.

Résumé

Dans cette étude comparative randomisée, 40 patients ont reçu une dose intraveineuse unique de 2 g de céphradine ou de 1,5 g de céfuroxime en tant que couverture prophylactique d'arthroplastie totale de hanche. Les concentrations sériques et osseuses de céphalosporine ont été plus élevées dans le groupe traité par la céphradine, en rapport avec l'utilisation d'une dose plus importante. Des concentrations osseuses adéquates ont été obtenues en moyenne avec les deux produits (25,34 mcg/g avec la céphradine et 17,39 mcg/g avec le céfuroxime) bien que la pénétration osseuse ait été plus variable avec le céfuroxime.

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References

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Correspondence to P. Woods.

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Cain, T.J., Jones, G.T. & Woods, P. Bone levels of cephradine and cefuroxime after intravenous administration in patients undergoing total hip replacement. International Orthopaedics 11, 61–63 (1987). https://doi.org/10.1007/BF00266059

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Key words

  • Hip replacement
  • intravenous administration
  • Cephradine
  • Cefuroxime