Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Extrapancreatic insulin effect of glibenclamide


In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone.

The rise in serum insulin levels persisted longer after glibenclamide. The initial rise in serum insulin was of the same magnitude in both situations, as was the rise in serum C-peptide levels during the entire 5 h study.

It is concluded that glibenclamide is able to maintain a more protonged increase in serum insulin levels by inhibiting the degradation of insulin in the vascular endothelial cells of the liver. The inhibition contributes to the blood glucose lowering effect of glibenclamide.

This is a preview of subscription content, log in to check access.


  1. 1.

    Jambon S, Chaptal J, Vedel A, Schaap J (1942) Accidents hypoglycemiques graves par un sulfamido-thiadiazol. Montpell Med 21: 441–445

  2. 2.

    Rafaelson OF (1959) Action of oral antidiabetic drugs on carbohydrate metabolism of isolated rat diafragm. Metabolism 8: 195–201

  3. 3.

    Feinglos MV, Leboritz HA (1978) Sulfonylureas increase the number of insulin receptors. Nature (London) 276: 184–187

  4. 4.

    Field JB (1973) Extraction of insulin by liver. Ann Rev Med 24: 309

  5. 5.

    Steiner DF, Kemmler W, Clark JL, Oyer PE, Rubenstein AH (1971) The biosynthesis of insulin. Handbook of Physiology, Section 7, Vol 1. American Physiological Society, Washington DC, pp 36–40

  6. 6.

    Rubenstein AM, Clark JL, Melani F, Steiner DF (1969) Secretion of proinsulin C-peptide by pancreatic B-cell and its circulation in blood. Nature 224: 697–699

  7. 7.

    Katz AL and Rubenstein AH (1973) Metabolism of proinsulin, insulin and C-peptide in the rat. J Clin Invest 52: 1113–1121

  8. 8.

    Kühl C, Faber OK, Homnes P, Lindkaer-Jansen S (1978) C-peptine metabolism and liver. Diabetes 27 [Suppl 1]: 197–200

  9. 9.

    Kaiser N, Vlodovsky I, Tur-Sinai A, Cerasi E (1982) Binding, internalization and degradation of insulin in vascular endothelial cells. Diabetes 31: 1077–1084

  10. 10.

    Sonksen PH, Tompkins CV, Srivastava MC, Nabarro JDN (1973) A comparative study on the metabolism of human insulin and porcine proinsulin in man. Clin Sci Mol Med 45: 103

  11. 11.

    Almer LO, Johansson E, Melander A, Wählin-Boll (1982) Influence of sulfonylureas on the secretion, disposal and effect of insulin. Eur J Clin Pharmacol 22: 27–32

  12. 12.

    Scheen AJ, Lefebvre PJ, Lugckx AJ (1984) Glipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients. Eur J Clin Pharmacol 26: 471–474

  13. 13.

    Marshall A, Gingerich RL, Wright PH (1970) Hepatic effect of sulfonylureas. Metabolism 19: 1046–1052

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mulder, H., Schopman, W. & van der Lely, A.J. Extrapancreatic insulin effect of glibenclamide. Eur J Clin Pharmacol 40, 379–381 (1991). https://doi.org/10.1007/BF00265847

Download citation

Key words

  • Insulin
  • glibenclamide
  • C-peptide
  • insulin catabolism
  • diabetes