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The effects of glycosaminoglycans, pyrophosphate and allopurinol treatment on urease-induced crystallization in vitro

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Summary

Previous studies have found that human urine inhibits urease-induced crystallization in synthetic urine. To identify the inhibitory components the effects of chondroitin sulphate, heparin and pyrophosphate on ureaseinduced crystallization were studied and the inhibitory capacity of human urine collected during and before/after allopurinol treatment compared. None of the substances studied nor allopurinol treatment was found to influence the urease-induced crystallization. These findings do not support the idea that glycosaminoglycans or pyrophosphate are responsible for the inhibitory effect detected in human urine.

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Hedelin, H., Grenabo, L. & Pettersson, S. The effects of glycosaminoglycans, pyrophosphate and allopurinol treatment on urease-induced crystallization in vitro. Urol. Res. 14, 305–307 (1986). https://doi.org/10.1007/BF00262380

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Key words

  • Urease-induced crystallization
  • Urinary tract concrements
  • Glycosaminoglycans
  • Pyrophosphate
  • Allopurinol