Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Compensatory renal hypertrophy II. During contralateral hydronephrosis

An Experimental study in dogs

  • 23 Accesses

Summary

Compensatory renal hypertrophy and hyperfunction during contralateral chronic hydronephrosis was investigated. It was found that graded impairment of the function in hydronephrotic kidneys causes proportional compensatory hypertrophy and hyperfunction in the contralateral kidney. The functional pattern both “per kidney” and “per nephron” was the same in the kidneys investigated here and in kidneys where contralateral nephrectomy had been performed, but whereas a decreased ability to concentrate the urine maximally and to reabsorb sodium was encountered in the latter, this could not be detected in this study. On the other hand, a decreased COSM in the diseased kidney did not stimulate a corresponding increase in the contralateral kidney as did unilateral nephrectomy. Adaptive and growth dependent changes in compensatory renal hypertrophy are discussed.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bialestock, D.: Microdissection of specimens of hydronephrosis with comparative nephron measurements. Aust. N. Z. J. Surg. 29, 211 (1960)

  2. 2.

    Bugge-Asperheim, B., Kiil, F.: Examination of growth-mediated changes in haemodynamics and tubular transport of sodium, glucose and hippurate after nephrectomy. Scand J. Clin. Lab. Invest. 22, 255 (1968)

  3. 3.

    Edvall, C. A.: Influence of ureteral obstruction (Hydronephrosis) on renal function in man. J. Appl. Physiol. 14, 855 (1959)

  4. 4.

    Elias, H., Hossmann, A., Barth, I. B., Solmor, A.: Blood flow in renal glomerulus. J. Urol. 83, 790 (1960)

  5. 5.

    Greenberg, S. R.: The bilateral effects occurring in hydronephrosis produced experimentally by various procedures. Urol. Int. 21, 1 (1966)

  6. 6.

    Hartman, M. E., Bonfilio, A. C.: Effect of nephrectomy on the minute renal circulation. Amer. J. Physiol. 196, 1119 (1959)

  7. 7.

    Hinman, F.: Renal counterbalance. J. Urol. 9, 289 (1923)

  8. 8.

    Hoeg, K.: Early renal tuberculosis and the resected kidney. Thesis. Philadelphia: F. A. David Company 1962

  9. 9.

    Milovidow, V. E.: The fate of the remaining kidney in nephrectomy. Int. Abstr. Surg. 70, 368 (1940)

  10. 10.

    Morrison, A. B., Howard, R. M.: The functional capacity of hypertrophied nephrons. Effect of partial nephrectomy on the clearance of Inulin and PAH in the rat. J. Exp. Med. 123, 829 (1966)

  11. 11.

    Moustgaard, J.: Om Proteinstoffernes Inflydelse paa Nyrefunktionen hos Hund. Thesis. København: Ejvind Christensen 1948

  12. 12.

    Olesen, S., Madsen, P. O.: Different techniques of developing experimental hydronephrosis in the dog. Invest. Urol. 7, 378 (1970)

  13. 13.

    Olesen, S., Genster, H.: Estimation of renal volume and function in dogs from the radiological appearance. Invest. Urol. 7, 363 (1970)

  14. 14.

    Olesen, S., Madsen, P. O.: Compensatory renal hypertrophy. I. Following unilateral nephrectomy. An experimental study in dogs. Urol. Res. 4, (1975)

  15. 15.

    Oliver, J.: When is a kidney not a kidney? J. Urol. 63, 373 (1950)

  16. 16.

    Rhoads, C. P., Alving, A. S., Hiller, A., Van Slyke, D. D.: Functional effect of explanting one kidney and removing the other. Amer. J. Physiol. 109, 329 (1934)

  17. 17.

    Rous, S. N., Wakim, K. G.: Kidney function before, during and after compensatory hypertrophy. J. Urol. 98, 30 (1967)

  18. 18.

    Schroeder, E.: Kliniske Studier over Nyrefunktionen hos Nephrectomerede. Thesis. København: Ejnar Munksgaard 1944

  19. 19.

    Wendth, A.: Drip infusin pyelography. Amer. J. Roentgenol. 95, 269 (1965)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Olesen, S., Madsen, P.O. Compensatory renal hypertrophy II. During contralateral hydronephrosis. Urol. Res. 3, 177–182 (1975). https://doi.org/10.1007/BF00261954

Download citation

Key words

  • Compensatory renal hypertrophy
  • Dogs
  • Hydronephrosis
  • Clearances