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Prevalence of diabetes among children of insulin-dependent diabetic mothers

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Summary

Eight diabetics were found among 464 children, mean age 11.2 years, of 311 unselected insulin-treated mothers. By a method of age correction the total diabetes prevalence among the children at the age of 25 years was calculated as 3.4%. Three children were non-insulin dependent and these patients and their mothers may belong to the autosomal dominant type of diabetes, so-called MODY. In two of the other five families the fathers also had insulin-dependent diabetes; in two more cases first or second degree paternal relatives were insulin-dependent diabetics. Thus the prevalence of insulin-dependent diabetes among the children of insulin dependent mothers married to non-diabetics is calculated as 1.5% at the age of 25 years.

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Köbberling, J., Brüggeboes, B. Prevalence of diabetes among children of insulin-dependent diabetic mothers. Diabetologia 18, 459–462 (1980). https://doi.org/10.1007/BF00261701

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Key words

  • Insulin-dependent diabetes
  • MODY
  • familial diabetes
  • genetics