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The influence of age and plasma glucagon on renal clearance of 99mTc-DTPA (Sn)

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Using an external arm counting technique and 99mTc-DTPA(Sn), as previously described (Macleod, Sampson & Houston, 1977), the glomerular filtration rate (GFR) of 120 subjects with normal renal function was measured and found to correlate significantly with age (r=0.91). Using the same technique in the investigation of 260 patients with a variety of diagnoses but who had normal renal function (GFR greater than 86 mls/min), 42 (16%) were found to clear the 99mTc-DTPA significantly faster. Twelve of these were subsequently found to be diabetic and to have significantly raised plasma glucagon levels. The remaining 30 also had significantly high plasma glucagon levels.

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Sampson, W.F.D., Macleod, M.A. & Houston, A.S. The influence of age and plasma glucagon on renal clearance of 99mTc-DTPA (Sn). Urol. Res. 8, 1–4 (1980). https://doi.org/10.1007/BF00261380

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Key words

  • Glomerular filtration rate
  • Age
  • Hyperclearance
  • Glucagon