Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Involvement of β-adrenoreceptors in the shift of ocular dominance after monocular deprivation

  • 36 Accesses

  • 45 Citations


In the visual cortex of young kittens, the extent of ocular dominance shift following brief monocular lid suture was less than expected in the hemisphere which had been locally perfused with β-adrenergic receptor blockers at a moderate concentration. The present result was not due to the effect similar to binocular deprivation, since “local anesthetic effect” of β-adrenergic blockers was unlikely to be involved in the present paradigm. Thus, the present results are consistent with the idea that β-adrenergic receptors within the visual cortex are necessary, at least in part, for the regulation of visuocortical plasticity.

This is a preview of subscription content, log in to check access.


  1. Adrien J, Buisseret P, Frégnac Y, Gary-Bobo E, Imbert M, Tassin J-P, Trotter Y (1982) Noradrénaline et plasticité du cortex visuel du chaton: un réexamen. CR Acad Sci Paris 295: 745–750

  2. Barlow HB, Blakemore C, Pettigrew JD (1967) The neural basis of binocular depth discrimination. J Physiol (Lond) 193: 327–342

  3. Bear MF, Daniels JD (1983) The plastic response to monocular deprivation persists in kitten visual cortex after chronic depletion of norepinephrine. J Neurosci 3: 407–416

  4. Bear MF, Paradiso MA, Schwartz M, Nelson SB, Carnes KM, Daniels JD (1983) Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity. Nature 302: 245–247

  5. Daw NW, Rader RK, Robertson TW, Ariel M (1983a) Effects of 6-hydroxydopamine on visual deprivation in kitten striate cortex. J Neurosci 3: 907–914

  6. Daw NW, Rader RK, Robertson TW, Videen TO (1983b) Do short term and long term depletion of noradrenaline have different effects on visual deprivation in the kitten visual cortex? Soc Neurosci Abstr 9: 1217

  7. Daw NW, Robertson TW, Rader RK, Videen TO, Coscia CJ (1984a) Substantial reduction of cortical noradrenaline by lesions of adrenergic pathways does not prevent effects of monocular deprivation. J Neurosci 4: 1354–1360

  8. Daw NW, Videen TO, Radar RK, Robertson TW (1984b) Intraventricular injection of 6-OHDA do not necessarily prevent the ocular dominance shifts that usually occur in the visual cortex of kittens after monocular deprivation. Soc Neurosci Abstr 10: 468

  9. Harden TK, Wolfe BB, Sporn JR, Poulos BK, Molinoff PB (1977) Effects of 6-hydroxydopamine on the development of the beta adrenergic receptor/adenylate cyclase system in rat cerebral cortex. J Pharmacol Exp Ther 203: 132–143

  10. Harik SI, Duckrow RB, La Manna JC, Rosenthal M, Sharma VK, Banerjee SP (1981) Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol-induced adenylate cyclase activity, and oxidative metabolism. J Neurosci 1: 641–649

  11. Hubel DH, Wiesel TN (1962) Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. J Physiol (Lond) 160: 106–154

  12. Hubel DH, Wiesel TN (1970) The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol (Lond) 206: 419–436

  13. Itakura T, Kasamatsu T, Pettigrew JD (1981) Norepinephrine-containing terminals in kitten visual cortex: laminar distribution and ultrastructure. Neuroscience 6: 159–175

  14. Jonsson G, Hallman H (1978) Changes in β-receptor binding sites in rat brain after neonatal 6-hydroxydopamine treatment. Neurosci Lett 9: 27–32

  15. Jonsson G, Kasamatsu T (1983) Maturation of monoamine neurotransmitters and receptors in cat occipital cortex during postnatal critical period. Exp Brain Res 50: 449–458

  16. Jonsson G, Wiesel FA, Hallman H (1979) Developmental plasticity of central noradrenaline neurons — changes in transmitter functions. J Neurobiol 10: 337–353

  17. Kasamatsu T (1979) Involvement of the β-adrenergic receptor in cortical plasticity. ARVO Abstr Suppl Invest Ophth Vis Sci 18: 135

  18. Kasamatsu T (1983) Neuronal plasticity maintained by the central norepinephrine system in the cat visual cortex. In: Sprague JM, Epstein AN (eds) Progr Psychobiol Physiol Psych, Vol 10. Academic Press, New York, pp 1–112

  19. Kasamatsu T, Itakura T, Jonsson G (1981) Intracortical spread of exogenous catecholamines: effective concentration for modifying cortical plasticity. J Pharmacol Exp Ther 217: 841–850

  20. Kasamatsu T, Itakura T, Jonsson G, Heggelund P, Pettigrew JD, Nakai K, Watabe K, Kuppermann BD, Ary M (1984) Neuronal plasticity in cat visual cortex: a proposed role for the central.noradrenaline system. In: Descarries L, Reader T, Jasper HH (eds) Monoamine innervation of cerebral cortex. Alan R Liss, New York, pp 301–319

  21. Kasamatsu T, Pettigrew JD, Ary M (1979) Restoration of visual cortical plasticity by local microperfusion of norepinephrine. J Comp Neurol 185: 163–182

  22. Kasamatsu T, Watabe K, Heggelund P, Schöller E (1985) Plasticity in cat visual cortex restored by electrical stimulation of the locus coeruleus. Neurosci Res (in press)

  23. Levick WR (1972) Another tungsten microelectrode. Med Biol Eng 10: 510–515

  24. Nakai K, Kasamatsu T (1984) Accelerated regeneration of central catecholamine fibers in cat occipital cortex: effects of substance P. Brain Res 323: 374–379

  25. Paradiso MA, Bear MF, Daniels JD (1983) Effects of intracortical infusion of 6-hydroxydopamine on the response of kitten visual cortex to monocular deprivation. Exp Brain Res 51: 413–422

  26. Pettigrew JD, Kasamatsu T (1978) Local perfusion of norepinephrine maintains visual cortical plasticity. Nature (Lond) 271: 761–763

  27. Shirokawa T, Kasamatsu T (1984) β-adrenergic receptor mediates neuronal plasticity in visual cortex. ARVO Abstr Suppl Invest Ophth Vis Sci 25: 214

  28. Wiesel TN, Hubel DH (1965) Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J Neurophysiol 28: 1029–1040

Download references

Author information

Correspondence to T. Kasamatsu.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kasamatsu, T., Shirokawa, T. Involvement of β-adrenoreceptors in the shift of ocular dominance after monocular deprivation. Exp Brain Res 59, 507–514 (1985). https://doi.org/10.1007/BF00261341

Download citation

Key words

  • β Adrenoreceptors
  • Neuronal plasticity
  • Ocular dominance
  • Monocular lid suture
  • Kitten visual cortex