Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster


We used a system with a mobilized Stalker transposable element, sometimes in combination with P-M hybrid dysgenesis, in the search for new mutations interfering with the y 2 mutation induced by mdg4 (gypsy) insertion into the yellow locus. A novel gene, modifier of mdg4, was detected in chromosome 3. The mutation mod(mdg4) either enhanced or suppressed phenotypic changes in different mutations induced by mdg4 insertions. Thus, mod(mdg4) seems to be involved in the control of mdg4 expression. Six other loci designated as enhancers of yellow were also detected. The e(y)n (with n from 1–6) mutations enhanced the expression of several y mutations induced by different insertions into the yellow locus. The major change is a damage of bristle and hair pigmentation which is not suppressed by su(Hw) mutations. On the other hand, e(y)n alleles do not interact with mdg4 induced mutations in other loci. All e(y)n genes are located in different regions of the X chromosome. One may speculate that e(y)n genes are involved in trans-regulation of the yellow locus and possibly of some other loci.

This is a preview of subscription content, log in to check access.


  1. Biessman H (1985) Molecular analysis of the yellow gene (y) region of Drosophila melanogaster. Proc Natl Acad Sci USA 82:7369–7373

  2. Campuzano S, Carramolino L, Cabrera CV, Ruiz Gomez M, Villares R, Boronat A, Modolell J (1985) Molecular genetics of the achete-scute gene complex of D. melanogaster. Cell 40:327–338

  3. Chia W, Howes G, Martin M, Meng YB, Moses K, Tsubota S (1986) Molecular analysis of the yellow locus of Drosophila. EMBO J 5:3597–3605

  4. Garcia-Bellido A (1986) Genetic analysis of morphogenesis. In: Gustaffson JP, Stebbins GL, Ayala FJ (eds) Genetics, Development and Evolution. Plenum Publishing Corporation, New York, pp 187–209

  5. Georgiev GP, Tchurikov NA, Ilyin YV, Georgieva SG, Mizrokhi LJ, Priimagi AF, Gerasimova TI, Georgiev PG, Simonova OB, Kiselev SL, Kochieva EZ (1989) Mobile genetic elements in Drosophila melanogaster (recent experiments). Genome, in press

  6. Georgiev PG, Mogila VA, Korochkina SE, Gerasimova TI (1986) Obtaining of Drosophila melanogaster strains with prolonged instability. Proc Acad Sci USSR (in Russian) 291:1492–1495

  7. Geyer PK, Corces VG (1987) Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster. Genes Dev 1:996–1004

  8. Geyer PK, Spana C, Corces VG (1986) On the molecular mechanism of gypsy induced mutations of the yellow locus of Drosophila melanogaster. EMBO J 5:2657–2662

  9. Green MM (1961) Complementation at the yellow locus in Drosophila melanogaster. Genetics 46:1385–1388

  10. Kidwell MG (1986) P-M mutagenesis. In: Roberts DB (ed) Drosophila: a practical approach. IRL Press, Oxford, pp 59–82

  11. Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Inst Wash Publ No 627

  12. Maniatis T, Goodbourn S, Fischer JA (1987) Regulation of inducible and tissue-specific gene expression. Science 236:1237–1244

  13. Mazo AM, Mizrokhi LJ, Karavanov AA, Sedkov YA, Krichevskaya AA, Ilyin YV (1989) Suppression in Drosophila: su(Hw) and su(f) gene products interact with a region of gypsy(mdg4) regulating its transcriptional activity. EMBO J 8:903–911

  14. Modolell J, Bender W, Meselson M (1983) Drosophila melanogaster mutations suppressible by the suppressor of Hairy wing are insertions of 7.3 kb mobile element. Proc Natl Acad Sci USA 8:1678–1681

  15. Nash WG (1976) Patterns of pigmentation color states regulated by the yellow locus in Drosophila melanogaster. Dev Biol 48:336–343

  16. Nash WG, Yarkin RJ (1974) Genetic regulation and pattern formation: a study of the yellow locus in Drosophila melanogaster. Genet Res 24:19–26

  17. Pardue ML (1986) In situ hybridization to DNA of chromosomes and nuclei. In: Roberts DB (ed) Drosophila; a practical approach. IRL Press, Oxford, Washington DC, pp 111–138

  18. Parkhurst SM, Corces VG (1986) Interaction among the gypsy transposable element and the suppressor of Hairy wing loci in Drosophila melanogaster. Mol Cell Biol 6:47–53

Download references

Author information

Correspondence to Tatiana I. Gerasimova.

Additional information

Communicated by B.H. Judd

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Georgiev, P.G., Gerasimova, T.I. Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster . Molec. Gen. Genet. 220, 121–126 (1989).

Download citation

Key words

  • Modifier of mdg4
  • Enhancers of yellow
  • Stalker
  • Yellow
  • mdg4 (gypsy)