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The stimulation of immunity and the induction of unresponsiveness to Trichuris muris in various strains of laboratory mice

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Summary

The development of the parasitic nematode Trichuris muris has been studied in 6 strains of laboratory mice. In each strain, the development of an acquired immunity was apparent during the first 2 or 3 weeks of a primary infection and this immunity resulted in the elimination of the primary worm population. Mice that had successfully eliminated a primary infection were protected against a subsequent challenge infection. Four of the strains contained a small proportion of individual mice which did not acquire immunity to infection. When cortisone acetate was given to the mice during a primary infection, a specific unresponsiveness to the parasite was induced and the primary population was not eliminated. The significance of these results is discussed in terms of a genetically controlled variation in immunological response to T. muris in strains of laboratory mice.

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References

  1. Campbell, W. C.: Spontaneous cure in Trichuris muris infections in albino mice and its suppression by cortisone. J. Parasit. 49, 628–632 (1963).

  2. — Collette, J. V.: Effect of cortisone upon infection with Trichuris muris in albino mice. J. Parasit. 48, 933–934 (1962).

  3. Wakelin, D.: Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–524 (1967).

  4. Wakelin, D.: Studies on the immunity of albino mice to Trichuris muris. The stimulation of immunity by chemically abbreviated infections. Parasitology 59, 549–555 (1969).

  5. — Studies on the immunity of albino mice to Trichuris muris. Suppression of immunity by cortisone acetate. Parasitology 60, 229–237 (1970).

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Wakelin, D. The stimulation of immunity and the induction of unresponsiveness to Trichuris muris in various strains of laboratory mice. Z. F. Parasitenkunde 35, 162–168 (1970). https://doi.org/10.1007/BF00259993

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Keywords

  • Acetate
  • Small Proportion
  • Cortisone
  • Primary Infection
  • Immunological Response