The development of the parasitic nematode Trichuris muris has been studied in 6 strains of laboratory mice. In each strain, the development of an acquired immunity was apparent during the first 2 or 3 weeks of a primary infection and this immunity resulted in the elimination of the primary worm population. Mice that had successfully eliminated a primary infection were protected against a subsequent challenge infection. Four of the strains contained a small proportion of individual mice which did not acquire immunity to infection. When cortisone acetate was given to the mice during a primary infection, a specific unresponsiveness to the parasite was induced and the primary population was not eliminated. The significance of these results is discussed in terms of a genetically controlled variation in immunological response to T. muris in strains of laboratory mice.
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Wakelin, D. The stimulation of immunity and the induction of unresponsiveness to Trichuris muris in various strains of laboratory mice. Z. F. Parasitenkunde 35, 162–168 (1970). https://doi.org/10.1007/BF00259993
- Small Proportion
- Primary Infection
- Immunological Response