The MSS51 gene product has been previously shown to be involved in the splicing of the mitochondrial pre-mRNA of cytochrome oxidase subunit I (COX1). We show here that it is specifically required for the translation of the COX1 mRNA. Furthermore, the paromomycin-resistance mutation (P inf454 supR ) which affects the 15 S mitoribosomal RNA, interferes, directly or indirectly, with the action of the MSS51 gene product. Possible roles of the MSS51 protein on the excision of COX1 introns are discussed.
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Communicated by C.P. Hollenberg
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Decoster, E., Simon, M., Hatat, D. et al. The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria. Molec. Gen. Genet. 224, 111–118 (1990). https://doi.org/10.1007/BF00259457
- Saccharomyces cerevisiae