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Dose-dependent pharmacokinetics of PMM in the rat

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Summary

Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 μg/mlxmin; plasma clearances were 0.042 and 0.027 l·kg-1·min-1, respectively.

These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.

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Correspondence to Maurizio D'Incalci.

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Colombo, T., Torti, L. & D'Incalci, M. Dose-dependent pharmacokinetics of PMM in the rat. Cancer Chemother. Pharmacol. 5, 201–203 (1981). https://doi.org/10.1007/BF00258481

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Keywords

  • Cancer Research
  • Plasma Level
  • Plasma Clearance
  • Metabolite Level
  • Level Curve