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The relationship between blood glycosylated haemoglobin and home capillary blood glucose levels in diabetics

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Summary

Serial capillary blood glucose levels from insulin treated patients were recorded over 24 hour periods at fortnightly intervals for three months. Total glycosylated haemoglobin as % of HbA was measured at the end of this period by the Flückiger method, and % HbA1 by column chromatography. There were highly significant correlations between mean blood glucose levels over the three months and % HbA1 (r=0.93, 95% confidence limits 0.84–0.98), and with total glycosylated haemoglobin (r=0.88, 95% confidence limits 0.75–0.94). There was also a good correlation between results obtained by the two methods (r=0.81, p<0.0001). There were less strong correlations between % HbA1 and blood glucose levels during each of the three months before the estimation, with percentage of glucose levels greater than 10 mmol/l and with mean fasting blood glucose. These data support the hypothesis that % HbA1 and total glycosylated haemoglobin are satisfactory measurements of short term diabetic control.

References

  1. 1.

    Sönksen PH, Judd SL, Lowy C (1978) Home monitoring of blood glucose. Lancet I: 729–732

  2. 2.

    Walford S, Gale EAM, Allison SP, Tattersall RB (1978) Selfmonitoring of blood glucose. Lancet I: 732–735

  3. 3.

    Wakelin K, Goldie DJ, Hartog M, Robinson AP (1978) Measurement of capillary blood glucose in filter-paper spots; an aid to the assessment of diabetic control. Br Med J II: 468–469

  4. 4.

    Trivelli LA, Ranney HM, Hong Tien L (1971) Haemoglobin components in patients with diabetes mellitus. N Engl J Med 284: 353–357

  5. 5.

    Huckiger R, Berger W, Winterhalter KH (1977) Haemoglobin A1c, a reliable index of diabetic control. Diabetologia 13: 393

  6. 6.

    Welch SG, Boucher BJ (1978) A rapid micro-scale method for the measurement of haemoglobin A1 (a+b+c). Diabetologia 14: 209–211

  7. 7.

    Koenig RJ, Peterson CH, Jones RL, Saudek C, Lehrman M, Cerami A (1976) Correlation of glucose regulation and haemoglobin A1c in diabetes mellitus. N Engl J Med 295: 417–420

  8. 8.

    Graf RJ, Halter JB, Porte D (1978) Glycosylated haemoglobin in normal subjects and subjects with maturity-onset diabetes. Diabetes 27: 834–839

  9. 9.

    Lance R, Soria J, Thibault N, Soria C, Eschwege E, Tchobroutsky G (1977) Glycosylated haemoglobin concentrations and clinitest results in insulin-dependent diabetes. Lancet II: 1156–1157

  10. 10.

    Gonen B, Rubenstein AH, Rochman H, Tanega SP, Horwitz DL (1977) Haemoglobin A1: An indicator of the metabolic control of diabetic patients. Lancet II: 734–736

  11. 11.

    Bunn HF, Gabbay KH, Gallop PM (1978) The glycosylation of Hb; relevance to diabetes mellitus. Science 200: 21

  12. 12.

    Elkeles RS, Wu J, Hambley J (1978) Haemoglobin a1, blood glucose and high density lipoprotein cholesterol in insulinrequiring diabetics. Lancet II: 547–548

  13. 13.

    Hill JB, Palmer PP (1969) Filter paper blood collection and punching as a means of quantification. Clin Chem 15: 381

  14. 14.

    Paisey R, Bradshaw P, Hartog M, West P (1979) Home monitoring of blood glucose using filter paper strips. Br Med J II: 1509

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Paisey, R.B., Macfarlane, D.G., Sherriff, R.J. et al. The relationship between blood glycosylated haemoglobin and home capillary blood glucose levels in diabetics. Diabetologia 19, 31–34 (1980). https://doi.org/10.1007/BF00258307

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Key words

  • Glycosylated haemoglobin
  • home blood glucose monitoring
  • diabetic control