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Studies on the nucleic acid metabolism of renal tumour cells in vitro

Summary

Renal tumours, obtained after nephrectomy, were subjected to in vitro study of the incorporation rate of C 14-8-adenine into nucleic acid bases.-In 10 examples of renal cell carcinoma, the incorporation rate into adenine and guanine were 2.01x10-2 (cpm/umole base) and 1.83x10-2 for DNA, and 3.00x10-2 and 2.83x10-2 for RNA. The incorporation rate in renal pelvic tumour was rather higher than that in renal cell carcinoma. It was demonstrated that the incorporation rate in Wilms tumour was highest.-These incorporation rates provide an index of the biological activity of the tumour cells.

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Takayasu, H., Aso, Y., Okada, K. et al. Studies on the nucleic acid metabolism of renal tumour cells in vitro. Urol. Res. 2, 39–41 (1974). https://doi.org/10.1007/BF00257947

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Key words

  • Nucleic acids
  • deoxyribonucleic acid (DNA)
  • ribonucleic acid (RNA)
  • incorporation rate
  • renal tumour
  • biological activity