Human uric acid renal stones are easily distinguished from other urinary calculi by their globular or spherical shape, their colour and their hardness. Investigations of uric acid crystals grown in the presence of a variety of pigments indicate that a disordered layer structure of the uric acid dihydrate is responsible for the colour of such crystals, caused by the inclusion of pigment molecules into the crystal lattice. This in turn may help to explain the other special properties of uric acid stones.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Kleeberg J, Warski E, Shalitin J (1974) Significance of staining uric acid crystals with natural and synthetic dyes. Proc Int Symp on Purine Metabolism. New York, Plenum Publ Co 41B: 829
Kleeberg J (1972) Färbung von Harnsäurekristallen mit Methylenblau. Z Urol Nephrol 65: 619
Kleeberg J, Weisz A (1982) The role of pigments in uric acid stone formation. Isr J Med Sc (In Press)
Lonsdale K, Mason P (1966) Uric acid, acid dihydrate and urates in urinary calculi, ancient and modern. Science 152: 1511
(1965) In: Oser BL (ed) Hawk's physiological chemistry. McGraw Hill Book Company, New York London (chap 30, p 1200)
Pinto B, Rocha E (1977) Urinary excretion of urocine. Invest Urol 15: 155
Pinto B, Rocha E (1976) Interaction of uricine with uric acid and its effect on uric acid precipitation. Invest Urol 14: 317
Ringertz H (1969) Stereochemical aspects of purine degradation. Ph. D. Dissertation. Dept. of Medical physica. Karolinska Institutet, Stockholm
Shirley R, Sutor D J (1966) Anhydrous uric acid: Nature and occurrence in urinary calculi. Science 159: 544
Thomas J M (1970) The chemistry of deformed and imperfect crystals. Endeavour 29: 149 (Bibliog)
About this article
Cite this article
Kleeberg, J., Gordon, T., Kedar, S. et al. Studies on the morphology of human uric acid stones. Urol. Res. 9, 259–261 (1981). https://doi.org/10.1007/BF00257774
- Uric acid crystals
- Renal stones