Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Intralymphatic infusion of interferon in patients with lymph nodal metastases from melanoma of the lower limbs

Summary

In five patients with regional lymph nodal metastases from malignant melanoma of the lower limbs, intralymphatic infusion of interferon caused a complete remission in one patient and a partial remission in two others. The remaining two patients, in whom the massive neoplastic infiltration had obstructed the inflow of the drug in the tumoural seat, were unresponsive. Since the efficacy of interferon seems to be dose-dependent, intralymphatic infusion causes the accumulation of massive quantities of the drug in the tumoural seat, thus favouring its antiproliferative action.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bocci V (1984) Evaluation of routes of administration of interferon in cancer: a review and a proposal. Cancer Drug Deliv 1: 337–351

  2. 2.

    Bonadonna G, Chiappa S, Musumeci R, Uslenghi C (1968) Endolymphatic radiotherapy in malignant lymphomas: a clinical evaluation of 285 patients. Cancer 22: 885–898

  3. 3.

    Borden EC (1983) Progress toward therapeutic application of interferons, 1973–1983. Cancer 54: 2770–2776

  4. 4.

    Cascinelli N, Balzarini GP, Fontana V, Orefice S, Veronesi U (1977) Intralymphatic administration of BCG in melanoma patients. Cancer Immunol Immunother 2: 157

  5. 5.

    Hadden JW (1987) Immunopharmacology: immunomodulation and immunotherapy. JAMA 258: 3005–3010

  6. 6.

    Juillard GJF, Boyer PJJ, Yamashiro CH, Snow HD, Weisenburger TH, McCarthy T, Miller RJ (1977) Regional intralymphatic infusion (ILI) of irradiated tumor cells with evidence of distant effects. Cancer 39: 126–130

  7. 7.

    Stein JA, Adler A, Goldfarb AJ, Czernobilsky B (1978) Direct endolymphatic instillation (ELI) of BCG-tumor cell mixture. Cancer Immunol Immunother 5: 31–39

  8. 8.

    Sulis E, Busilacchi M, Turno R, Monni A, Chessa A, Zizi P, Pani P, Manconi PE (1976) Administration of antigen by intralymphatic route in the rat. Humoral response to soluble antigens. Preliminary report. Boll Ist Sieroter Milan 55: 249–251

Download references

Author information

Correspondence to Efisio Sulis.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sulis, E., Floris, C. & Massidda, C. Intralymphatic infusion of interferon in patients with lymph nodal metastases from melanoma of the lower limbs. Cancer Chemother. Pharmacol. 24, 393–394 (1989). https://doi.org/10.1007/BF00257450

Download citation

Keywords

  • Melanoma
  • Nodal Metastasis
  • Cancer Research
  • Interferon
  • Complete Remission