The analogic liver scintigram using 99mTc sulfur colloid in cirrhotic patients does not permit determination of the nature of the areas of decreased uptake.
Scintigrams with 67Ga citrate generally show increased activity in cases of hepatoma. In some cases, however, 67Ga citrate is less concentrated in neoplasic tissue and it is not possible to detect a tumoral lesion in a cirrhotic liver.
This is why we used double isotope scintigraphies with 67Ga citrate and 99mTc sulfur colloïd, with digital subtraction, after simultaneous recording of 99mTc and 67Ga data on magnetic tape by means of an interface. In our series of 22 patients, the comparison of the results obtained by this double isotope technique with histology showed no false positive in subtraction scintigrams. There was one false negative because of the lack of significance in the subtracted image for one of the six patients with cancer of the liver. For three of the six patients with hepatoma, the gallium scintigram showed an increased uptake in the tumor area. For the three other cases, the gallium uptake was equilibrated throughout the liver scintigraphy.
It was therefore in cases where the gallium scintigram showed no increased activity that the subtraction technique was of greatest value, for it permitted the diagnosis of hepatoma in two cases.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Blanquet, P.C., Beck, C.R., Fleury, J., Palais, C.J.: Pancreas scanning with 75 Se selenomethionine and 198 Au using digital-data-processing techniques. J. nucl. Med. 9, 486 (1968)
Caroli, J., Milhaud, G., Saint-Laurent, J.E. de, Hadchouel, P., Theodoropoulos, G.: Methode originale de diagnostic des cancers du foie. La scintigraphie à la sélénométhionine. Ann. Méd. Interne 122, 747–754 (1971)
Edwards, C.L., Hayes, R.L.: Tumor scanning with 67 Ga-citrate. J. nucl. Med. 10, 103–105 (1969)
Hamamoto, K.: Usefulness of computer scintigraphy for detecting liver tumor with 67 Ga citrate and the scintillation camera. J. nucl. Med. 13, 667 (1972)
Hisada, K., Ando, A.: Studies of affinity of the elements in group III in the periodic table for malignant tumors. Radioisotopes (Tokyo) 20, 171–179 (1971)
Kaplan, E., Ben Porath, M.: Elimination of liver interference from the selenomethionine pancreas scan. J. nucl. Med. 7 807 (1966)
Paola, R. di, Bazin J.P., Parmentier, C., Todd-Pokropek, A.E., Tubiana, M., (Institut Gustave Roussy), Zajde, C., Bosshard, R., (Orsay): Système en ligne adapté au traitement des informations scintigraphiques. Internat. Atomic Energy Agency, Vienne, Vol. 1, 571 (1973)
Suzuki, T.: Positive scintiphotography of cancer of the liver with Ga 67 citrate. Amer. J. Roentgenol. 113, 92–103 (1971)
About this article
Cite this article
Moreau, R., Soussaline, F., Chauvaud, S. et al. Detection of hepatoma in liver cirrhosis. Eur J Nucl Med 2, 183–188 (1977). https://doi.org/10.1007/BF00257278
- Liver Cirrhosis
- Cirrhotic Patient
- Cirrhotic Liver
- Magnetic Tape