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Investigations into the use of 77Br labelled 5α-dihydrotestosterone for scanning the prostate

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The potential use of a potent androgen labelled with a gamma emitting radionuclide for scanning the prostate was investigated. 2αbromo 5α-dihydrotestosterone was synthesized and subsequently labelled with 77Br. The distribution of this compound was studied in rat and human tissues. The maximum concentration of radioactivity in the rat prostate at 1–4 h following the injection was found to be between 0.5–0.8% of the injected dose per gram of the tissue. In the human however, that value was 0.002–0.003%. Considering the overall results it was concluded that this compound is not appropriate for scanning the prostate.

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  1. Berger, B., Coffey, D.S., Scott, W.W.: Concepts and limitations in the application of radiolabelled antiandrogens, estrogens and androgens as isotopic scanning agents for the prostate. Invest. Urol. 13, 10–16 (1975)

  2. Chisholm, G.D., Short, M.D., Ghanadian, R., McRae, C.U., Glass, H.I.: Radiozinc uptake and scintiscanning in prostatic disease. J. Nucl. Med. 15, 739–742 (1974)

  3. Ghanadian, R., Fotherby, K.: Interaction between steroids in regard to their uptake by rat prostate. Steroids Lipids Res. 3, 367–371 (1972)

  4. Ghanadian, R., Waters, S.L., Thakur, M.L., Chisholm, G.D.: Studies with radioactive iodine labelled oestrogens as prostate scanning agents. Int. J. appl. Radiat. 26, 343–346 (1975)

  5. Ghanadian, R., Waters, S.L., Williams, G., Chisholm, G.D.: The use of 123I labelled oestradiol in detecting the human prostate using a gamma camera. Eur. J. Nucl. Med. 1, 159–160 (1976a)

  6. Ghanadian, R., Chisholm, G.D., Fotherby, K.: Intracellular localisation of 5α-dihydrotestosterone in human benign prostatic hypertrophy. Clin. chim. Acta. 73, 521–526 (1976b)

  7. Johnston, G.S., Wade, J.C., Murphy, G.P., Scott, W.W.: 65Zn and 69mZn studies in the dog, monkey and man. J. Surg. Res. 8, 528–534 (1968)

  8. Jones, B.J., Ship, S.: Inhibition of the 3-keto steroid 157-1 of pseudomonas testosterone by some bromo-3-ketosteroid derivatives. Biochem. Biophys. Acta 258, 800–809 (1972)

  9. Shida, K., Shimazaki, J., Kurihara, H., Ito, Y.: Scintiscanning of the prostatic tumours with 131I labelleld sex hormones. Proc. First World Congress of Nuclear Medicine, 674–676, Tokyo (1974)

  10. Skinner, R.W., Pozderac, R.V., Counsell, R.E., Weinhold, P.A.: The inhibitive effect of steroid analogues in the binding of tritiated 5α-dihydrotestosterone to receptor proteins from rat prostate tissue. Steroids 25, 189–202 (1975)

  11. Szendroi, Z., Kocsar, L., Karika, Z., Eckhart, S.: Isotope scanning of the prostate. Lancet 1, 1252–1253 (1973)

  12. Tubis, M., Sendow, J.S., Blahd, W.H.: The distribution of 131I labelled diethylstilboestrol diphosphate in animals and men with observations on its use as a scanning agent of the prostate. Nucl.-Med. 6, 184–202 (1967)

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Correspondence to Dr. R. Ghanadian.

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Ghanadian, R., Waters, S.L. & Chisholm, G.D. Investigations into the use of 77Br labelled 5α-dihydrotestosterone for scanning the prostate. Eur J Nucl Med 2, 155–157 (1977). https://doi.org/10.1007/BF00257273

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  • Public Health
  • Radionuclide
  • Androgen
  • Nuclear Medicine
  • Maximum Concentration