The potential use of a potent androgen labelled with a gamma emitting radionuclide for scanning the prostate was investigated. 2αbromo 5α-dihydrotestosterone was synthesized and subsequently labelled with 77Br. The distribution of this compound was studied in rat and human tissues. The maximum concentration of radioactivity in the rat prostate at 1–4 h following the injection was found to be between 0.5–0.8% of the injected dose per gram of the tissue. In the human however, that value was 0.002–0.003%. Considering the overall results it was concluded that this compound is not appropriate for scanning the prostate.
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Ghanadian, R., Waters, S.L. & Chisholm, G.D. Investigations into the use of 77Br labelled 5α-dihydrotestosterone for scanning the prostate. Eur J Nucl Med 2, 155–157 (1977). https://doi.org/10.1007/BF00257273
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