Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Lactoferrin in human prostate tissue

Summary

Lactoferrin levels have been determined by radialimmunodiffusion in homogenates of both human benign prostatic hypertrophy obtained at open surgery from patients, some of whom had been treated with oestrogens or antiandrogens, and also in prostatic adenocarcinoma tissue removed by transurethral resection. Results show that in untreated benign prostatic hyperplasia there is a statistically lower lactoferrin level in the median compared with the lateral lobes. In patients with benign prostatic hypertrophy treated before prostatectomy with oestrogens or antiandrogens the lactoferrin concentration is decreased. In neoplastic tissue removed by open surgery, the lactoferrin level is very low. Homogenates of tissue resected from protatic cancer patients show similarly low levels. The concentration of lactoferrin in human prostate is hormone dependent. The role of the protein is considered to be bacteriostatic.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bluard-De Coninck J M, Williams J, Evans RW, Van Snick J, Osinski PA, Masson PL (1978) Iron-binding fragments from the N-terminal and C-terminal regions of human lactoferrin. Biochem 171: 321

  2. 2.

    De Laey P, Masson PL, Heremans JF (1969) The role of lactoferrin in iron adsorption. In: H. Peeters (ed.) Protides of the biological fluids. Pergamon, Oxford p 627

  3. 3.

    Doumas BT (1975) Standards for total serum protein assays. A collaborative study. Clin Chem 21: 1159

  4. 4.

    Haupt H, Baudner S (1973) Isolierung und Kristallisation von Lactoferrin aus Human-Kolostsrum. Hoppe Seylers Z Physiol Chem 354: 944

  5. 5.

    Heckman A, Rümke P (1969) The antigens of human seminal plasma (with special reference to lactoferrin as a spermatozoa-coating antigen). In: H. Peeters (ed.) Protides of the biological fluids. Pergamon, Oxford p 549

  6. 6.

    Loisillier F, Got R, Burtin P, Grabar P (1967) Recherches sur la localisation tissulaire et l'autoantigénicité de la lactoferrine. In: H. Peeters (ed.) Protides of the biological fluids. Elsevier, Amsterdam p 133

  7. 7.

    Mancini G, Carbonara AO, Heremans JF (1965) Immuno-chemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2: 235

  8. 8.

    Markowetz B, Van Snick JL, Masson PL (1979) Binding and indigestion of human lactoferrin by mouse alveolar macrophages. Thorax 34: 209

  9. 9.

    Masson PL, Hermans J F (1967) Studies on lactoferrin, the ironbinding protein of secretions. In: H. Peeters (ed.) Protides of the biological fluids. Elsevier, Amsterdam p 115

  10. 10.

    Masson PL, Hermans JF, Dive C (1966) An iron-binding protein common to many external secretions. Clin Chim Acta 14: 735

  11. 11.

    Masson PL. Hermans JF, Prignot JJ, Wauters G (1966) Immunohistochemical localization and bacteriostatic properties of an iron-binding protein from bronchial mucus. Thorax 21: 538

  12. 12.

    Masson PL, Hermans JF, Ferin J (1968) Presence of an iron-binding protein (lactoferrin) in the genital tract of the human female. Fertil Steril 19: 679

  13. 13.

    Masson PL, Hermans JF, Schonne E (1969) Lactoferrin, an ironbinding protein in neutrophilic leukocytes. Jexp Med 130: 643

  14. 14.

    Masson PL, Hermans JF, Schonne E. Crabbé PA (1969) New data on lactoferrin, the iron-binding protein of secretions. In: H. Peeters (ed.) Protides of the biological fluids. Pergamon, Oxford p 633

  15. 15.

    Oram JD, Reitner B (1968) Inhibition of bacteria and other iron-chelating agents. Biochem Biophys Acta 170: 351

  16. 16.

    Roberts TK, Masson PL, Heremans JF (1973) Heterogeneity of human lactoferrin. Immunology of reproduction. Bulgarian Academy of Sciences, Sofia p 706

  17. 17.

    Sørensen M, Sørensen SP (1939) The proteins in whey. C R des Travaux du Laboratoire Carlsberg 23:55

  18. 18.

    Van Camp K (1967) Biologische onderzoekingen op prostaatweefsel. Arscia, Brussels p 32

  19. 19.

    Van Camp K, van Sande M (1980) Vrije aminozuren en ninhydrine positieve substanties in menselijk prostaatweefsel. Verh K Acad Geneeskd Belg 42: 104

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

van Sande, M., Van Camp, K. Lactoferrin in human prostate tissue. Urol. Res. 9, 241–244 (1981). https://doi.org/10.1007/BF00256894

Download citation

Key words

  • Prostate
  • Lactoferrin