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Multiple organ failure during interleukin-2 administration and LAK cells infusion

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Adoptive immunotherapy is a new promising treatment for cancer but is associated with severe toxicity mainly related to a capillary leak syndrome. We report the case of a patient with metastatic hypernephroma, who had many complications such as coma, renal failure, pulmonary edema, life-threatening acidosis, cardiac arrhythmias and venous thrombosis. Critical care specialists should be aware of this type of cancer therapy because of multiple side effects requiring ICU supportive care.

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Sculier, J.P., Bron, D., Verboven, J. et al. Multiple organ failure during interleukin-2 administration and LAK cells infusion. Intensive Care Med 14, 666–667 (1988). https://doi.org/10.1007/BF00256776

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Key words

  • Immunotherapy
  • Cancer
  • Interleukin-2
  • Capillary leak syndrome