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Chemosensitivity of murine renal carcinoma

Summary

A non-endocrine dependent, spontaneous carcinoma of the kidney in a Wistar-Lewis rat has been studied for sensitivity to chemotherapeutic agents. Two tumour models have been employed. Subcutaneously transplanted flank nodules were used to screen single agents for antitumour activity. A model of intraperitoneal metastatic disease was employed to test further agents which had demonstrated some effectiveness in the nodule model. Single agents that proved ineffective were streptozotocin, neocarzinostatin, chlorozotocin and carminomycin. 5-FU, bleomycin and hydroxyurea were also ineffective at the doses tested. Agents that were effective included cyclophosphamide, adriamycin, vinblastine, vindesin, and maytansine. The most effective combination therapy appeared to be cyclophosphamide with vindesin and cisplatin.

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References

  1. 1.

    Baumgartner S, Heinz R, Schaller J (1979) Treatment of hypernephroma with methotrexate alone or in combination followed by citrovorum factor rescue. Wien Med Wochenschr 129:407

  2. 2.

    deVere White R, Olson CA (1980) Renal adenocarcinoma in the rat. Invest Urol 17:405

  3. 3.

    deVere White R, Previte S, Olson CA (1978) A new animal model for testing effectiveness of chemotherapeutic agents on renal adenocarcinoma. Surg Forum 29:629

  4. 4.

    Hrushesky WJ, Murphy GP (1973) Evaluation of chemotherapeutic agents in a new murine renal carcinoma model. J Natl Cancer Institute 50:1013

  5. 5.

    Hrushesky WJ, Murphy GP (1977) Current status of the therapy of advanced renal carcinoma. J Surg Oncol 9:277

  6. 6.

    Levi JA, Dalley D, Aroney R. A comparative trial of the combination vinblastine (v), methotrexate (a) and bleomycin (b) with and without tamoxifen (t)

  7. 7.

    Levi JA, Dalley D, Aroney R (1980) Adjuvant chemotherapy of renal cell carcinoma using a combination of bleomycin (BLM) and lomustine (CCNA). Procedure of the American Association of Cancer Research 21:362

  8. 8.

    Murphy GP, Hrushesky WJ (1973) A murine renal cell carcinoma. J Natl Cancer Institute 50:1013

  9. 9.

    Richards F, Muss HB, White DR, Cooper MR, Spurr CC (1977) CCNU, bleomycin and methylprednisolone with or without adriamycin in renal cell carcinoma: A randomized trial. Cancer Treat Rep 61:1591

  10. 10.

    Samson MK, Baker LJ, Devos JM, Baroker TR, Roick RM, Vaitkevicius CK (1976) Phase I clinical trial of combined therapy with vinblastine (NSE 1, 981, 2), bleomycin (WSC-125066) and cisdishlorodiammineplatinum (11)(WSC-119875). Cancer Treat Rep 60:91

  11. 11.

    Shefner AM, Marlow M (1975) Preliminary drug trials in a renal adenocarcinoma animal model. Cancer Chemother Rep. 5:145

  12. 12.

    Soloway MS, Myers GH Jr (1973) The effect of hormonal therapy on a transplantable renal cortical adenocarcinoma in syngeneic mice. J Urol 109:356

  13. 13.

    Sufrin G, Murphy GP (1977) Pharmacokinetic studies of a transplantable murine renal adenocarcinoma. Invest Urol 15:9

  14. 14.

    Talley RW, Oberhanger NA, Browlee RW, O'Bryan RM (1979) Chemotherapy of metastastic renal adenocarcinoma with a five-drug regimen. Henry Ford Hosp Med J 27:110

  15. 15.

    Todd RF, Garnick MB, Canellos GP (1980) Chemotherapy of advanced renal adenocarcisoma with methylgloxal-bis-suanylhydrazone (methyl-GAG). Procedure of the American Association of Cancer Research 21:3110

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Supported by VA Grant No. 821-103

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deVere White, R., Ki Hong, W., Tannenbaum, T. et al. Chemosensitivity of murine renal carcinoma. Urol. Res. 10, 27–30 (1982). https://doi.org/10.1007/BF00256520

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Key words

  • Renal carcinoma
  • Chemosensitivity
  • Animal model