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E. coli adherence to bladder epithelial cells of mice

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Adherence of E. coli to bladder cells was studied by mixing E. coli with cells scraped from the surface of the normal mouse bladder. E. coli adherence to bladder epithelium did not correlate with renal infection, the ability of E. coli to resist phagocytosis, the growth of the strains, the presence of K-antigen or dulcitol fermentation. There was also no correlation with proportion of deaths, motility, or rough mutation. Pili were observed in three of the 22 strains of E. coli and their presence was not associated with increased virulence. In this model of renal infection neither adherence of E. coli to bladder epithelial cells nor the presence of pili were significant virulence factors.

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  1. 1.

    Brinton, C. C., Jr.: The structure, function, synthesis and genetic control of bacterial pili and a molecular model for DNA and RNA transport in gram negative bacteria. Transactions of the New York Academy of Science 27, 1003–1054 (1965)

  2. 2.

    Duguid, J. P.: fimbriae and adhesive properties in Klebsiella strains. Journal of General Microbiology 21, 271–286 (1959)

  3. 3.

    Eden, C. S., Jodal, U., Hanson, L. A., Lindberg, U., Akerlund, A. S.: Variable adherence to normal human urinary-tract epithelial cells of Escherichia coli strains associated with various forms of urinary-tract infection. Lancet 2, 490–492 (1976)

  4. 4.

    Gibbons, R. J., van Houte, J.: Selective bacterial adherence to oral epithelial surfaces and its role as an ecological determinant. Infection and Immunity 3, 567–573 (1971)

  5. 5.

    Guze, L. B., Montgomerie, J. Z., Potter, C. S., Kalmanson, G. M.: Pyelonephritis XVI. Correlates of parasite virulence in acute ascending Escherichia coli pyelonephritis in mice undergoing diuresis. Yale Journal of Biology and Medicine 46(3), 203–211 (1973)

  6. 6.

    Lancet: Bacterial stickiness. Lancet 1, 716–717 (1974)

  7. 7.

    Punsalang, A. P., Sawyer, W. D.: Role of pili in the virulence of Neisseria gonorrhoeae. Infection and Immunity 8, 255–263 (1973)

  8. 8.

    Shea, S. M.: The evaluation of laboratory data. In: L. B. Page and P. J. Culver (eds.). A Syllabus of Laboratory Examination in Clinical Diagnosis. Harvard University Press, Cambridge, Mass., pp. 15–20 (1962)

  9. 9.

    Silverblatt, F. J.: Host-parasite interaction in the rat renal pelvis. Journal of Experimental Medicine 140, 1696–1711 (1974)

  10. 10.

    Staley, T. E., Jones, E. W., Corley, L. D.: Attachment and penetration of Escherichia coli into intestinal epithelium of the ileum in new born pigs. American Journal of Pathology 56, 371–381 (1969)

  11. 11.

    Silverblatt, F. J., Ofek, I.: Influence of pili on the virulence of Proteus mirabilis in experimental hematogenous pyelonephritis. Journal of Infectious Diseases 138, 664–667 (1978)

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Montgomerie, J.Z., Turkel, S., Kalmanson, G.M. et al. E. coli adherence to bladder epithelial cells of mice. Urol. Res. 8, 163–165 (1980). https://doi.org/10.1007/BF00256411

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Key words

  • Urinary Tract Infection
  • E. coli Adherence
  • Pili