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In-vivo and ex-vivo renal preservation

preliminary observations

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Summary

A new renal perfusate of modified intracellular electrolyte composition made hyperosmolar with mannitol and requiring no additional additives was successfully used to preserve canine kidneys “ex-vivo” for 48 hours by initial perfusion and hypothermic storage. The new perfusate was also successful in protecting totally ischemic canine kidneys from the lethal effect of two-hours of normothermic exposure “in-vivo”. — The preservation technique is uncomplicated, the materials involved are inexpensive, and the preservation apparatus is readily transportable.

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Supported by the Max Kade Foundation, New York, New York.

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Sacks, S.A., Petritsch, P.H., Battenberg, J.D. et al. In-vivo and ex-vivo renal preservation. Urol. Res. 1, 83–87 (1973). https://doi.org/10.1007/BF00256124

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Key words

  • Renal preservation
  • renal transplantation
  • hypothermia
  • normothermia
  • hyperosmolar intracellular electrolyte solution