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Experimental techniques for testing the sensitivity of bladder tumours to antineoplastic drugs

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Summary

A number of laboratory tests can be employed to examine the sensitivity of human bladder tumour cells to various chemotherapeutic agents.-Their principles and methods, and some preliminary results, are described with special reference to certain in vitro and in vivo cytotoxicity tests and to heterotransplantation in the hamster. Satisfactory agreement has sometimes been observed between experimental results and clinical responses, but our experience is still very limited.-The employment of several such tests would probably lead to a greater degree of reliability in the laboratory assessment of the sensitivity of bladder tumours to cytotoxic drugs.

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Pavone-Macaluso, M., Gebbia, N., Biondo, F. et al. Experimental techniques for testing the sensitivity of bladder tumours to antineoplastic drugs. Urol. Res. 1, 60–66 (1973). https://doi.org/10.1007/BF00256120

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Key words

  • Bladder papilloma
  • bladder carcinoma
  • tomour chemotherapy
  • screening of anticancer compounds