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Characterization of polymerized vesicles derived from polymerizable 1,3-diacylglycero-2-phosphocholines: formation of large unilamellar vesicles by ultrasonication

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Summary

A series of polymerizable lipids, 1,3-bis(alkana-2,4-dienoyl)-rac-glycero-2-phosphocholines, and 1-(alkana-2,4-dienoyl)-2-0-alkyl-rac-glycero-3-phosphocholine were synthesized. Their vesicle formation and photopolymerization to form polymerized and single walled vesicles were elucidated. The acyl chain length remarkably affected features of liposome formation. 1,3-Bis(dodeca-2,4-dienoyl)-rac-glycero-2-phosphocholine gave large unilamellar vesicles only by ultrasonication of the suspended powders in water, but the lipids with longer acyl chain(s) formed normal and small unilamellar vesicles.

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References

  1. 1.

    This forms part 6 of a series entitled “Synthesis and properties of polymerizable phospholipids”. Part 5: Y. Matsushita, E. Hasegawa, K. Eshima, H. Ohno and E. Tsuchida, Makromol. Chem. Rapid Commun. (1986) in press.

  2. 2.

    G. Gregoriadis ed., “Liposome Technology, Vol. II”, CRC Press, Inc., Flo., USA(1983).

  3. 3.

    D. A. Tirrell, L. G. Donaruma and A. B. Truek, eds., “Macromolecules as Drugs and as Carriers for Biologically active Materials”, The New York Acad. Sci., New York, NY, USA(1985).

  4. 4.

    J. H. Fendler, “Membrane Mimetic Chemistry”, John Wiley & Sons, NY, USA (1984).

  5. 5.

    H. Bader, H. Ringsdorf and B. Schmidt, Angew. Makromol. Chem. 124/125 457 (1984).

  6. 6.

    H. Hauser, TIPS 3 227 (1982).

  7. 7.

    G. Gregoriadis ed.,“Liposome Technology, Vol. I” (1983).

  8. 8.

    C. Huang and T. E. Thompson, Methods Enzymol. 32 485 (1974).

  9. 9.

    D. Deamer and A. D. Bangham, Biochim. Biophys. Acta 443 629 (1976).

  10. 10.

    J. Brunner, P. Skrabal and H. Hauser, ibid 455 332 (1976).

  11. 11.

    F. Szoka and D. Papahadjopoulos, Proc. Nat. Acad. Sci. USA 75 4194 (1978).

  12. 12.

    H. Hauser and N. Gains, ibid 79 1683 (1982).

  13. 13.

    C. Huang and J. T. Mason, 75 308 (1978).

  14. 14.

    S.W. Provencher, J. Hendrix and I. De Maeyer, J. Chem. Phys. 69 4273 (1978).

  15. 15.

    M. E. Himmel and P. C. Squire, J. Chromatogr. 210 443 (1981).

  16. 16.

    E. Hasegawa, Y. Matsushita, K. Eshima, H. Nishide and E. Tsuchida, Makromol. Chem. Rapid Commun. 5 779 (1984).

  17. 17.

    E. Hasegawa, K. Eshima, Y. Matsushita, H. Nishide and E. Tsuchida, Polymer Bull. 14 31 (1985).

  18. 18.

    E. Hasegawa, Y. Matsushita, K. Eshima, H. Ohno and E. Tsuchida, ibid 15 397 (1986).

  19. 19.

    M. Ollivon, A. Walter and R. Blumenthal, Anal. Biochem. 152 262 (1986).

  20. 20.

    K. Dorn, R. T. Klingbiel, D. P. Specht, P. N. Tyminski, H. Ringsdorf and D. F. O'Brien, J. Amer. Chem. Soc. 106 1627 (1984).

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Hasegawa, E., Eshima, K., Matsushita, Y. et al. Characterization of polymerized vesicles derived from polymerizable 1,3-diacylglycero-2-phosphocholines: formation of large unilamellar vesicles by ultrasonication. Polymer Bulletin 18, 65–71 (1987). https://doi.org/10.1007/BF00255824

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Keywords

  • Lipid
  • Polymer
  • Chain Length
  • Material Processing
  • Acyl Chain