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The effect of various drugs on canine ureteric peristalsis

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Summary

Using an intact concious animal model the effect of various drugs on the rate of canine ureteric peristalsis was studied. The drugs found to reduce consistently the rate of ureteric peristalsis were diazoxide, terbutaline, and ritodrine. Ritodrine was the most consistent, having a prolonged effect and reducing the rate of ureteric peristalsis to 50% of the rates observed in control experiments.

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References

  1. 1.

    Baker R, Huffer J (1953) Electromyography in the normal, dilated, transected and transplanted ureter. Am J Physiol 174: 381–390

  2. 2.

    Boyarsky S, Laby PC (1972) Ureteral dynamics. Williams and Wilkins, Baltimore

  3. 3.

    Boyarsky S, Martinez J (1962) Ureteral peristaltic pressures in dogs with changing urine flows. J Urol 87:25–32

  4. 4.

    Butcher HR, Sleator W, Schmandt WP (1957) A study of the peristaltic conduction mechanism in the canine ureter. J Urol 78:221–231

  5. 5.

    Dale RL, Constantinou CE, Briggs EM, Govan DE (1971) Dynamics of the upper urinary tract: The effects of an indwelling ureteral catheter on ureteral peristalsis. Invest Urol 8:655–672

  6. 6.

    Golenhofen K, Lammel E (1972) Selective suppression of some components of spontaneous activity in various types of smooth muscle by Iproveratril (Verapamil). Pflügers Arch 331:233–243

  7. 7.

    Grauers O, Samsoe PD, Hasselgren KH, Ingemansson S, Westberg R (1982) Metoclopramide in acute pain caused by gall bladder or kidney stones (Abstract) Scand J Gastroenterol 17 (Suppl 78):223

  8. 8.

    Kubacz GJ, Catchpole BN (1977) The role of adrenergic blockade in the treatment of ureteral colic. J Urol 15:2445–2451

  9. 9.

    Lehtonen T (1973) Effect of Aminophylline on passage of ureteral concretions. Ann Chir Gynaecol Fenn 62:90–92

  10. 10.

    Malin J, Deane RF, Boyarsky S (1970) Characterisation of adrenergic receptors in human ureter. Br J Urol 42:171–174

  11. 11.

    Mayo ME, halbert SA (1981) The effect of glucagon and diazoxide on the normal and obstructed upper urinary tract. Urol Int 36:100–109

  12. 12.

    Melchior H, Lymberopoulos S, Lutzeyer W (1971) Spasmolyse durch Beta-Adrenergica. Urologe 10:183–188

  13. 13.

    Peters HJ, Eckstein W (1975) Possible pharmacological means of treating renal colic. Urol Res 3:55–59

  14. 14.

    Reid RE, Herman R, Teng CS (1974) Attempts at altering ureteral activity in the unaesthetised, conditioned dog with commonly employed drugs. Invest Urol 12:74–78

  15. 15.

    Schelin S (1979) Observations on the effect of metoclopramide (Primperan) on the human ureter. Scan J Urol Nephrol 13:79–82

  16. 16.

    Stower MJ, Wright JW, Hardcastle JD (1983) The action of glucagon and commonly used antispasmodics and analgesics on the canine ureter. Br J Surg 70:89–91

  17. 17.

    Struthers NW (1973) An experimental model for evaluating drug effects on the ureter. Br J Urol 45:23–27

  18. 18.

    Washizu Y (1968) Ouabain on excitation contraction in the guinea pig ureter. Fed Proc 27:662

  19. 19.

    Weiss RM, Bassett AL, Hoffman BF (1970) The effect of Ouabain on contractility of the isolated ureter. Invest Urol 8:161–169

  20. 20.

    Weiss RM, Vulliemoz Y, Verosky M, Rosen MR, Triner L (1977) Adenylate cyclase and phosphodiesterase activity in rabbit ureter. Invest Urol 15:15–18

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M. J. Stower was in receipt of a grant from Novo Industries

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Stower, M.J., Clark, A.G., Wright, J.W. et al. The effect of various drugs on canine ureteric peristalsis. Urol. Res. 14, 41–44 (1986). https://doi.org/10.1007/BF00255532

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Key words

  • Ureter
  • Propanolamines