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Hypophosphatemia and acute respiratory failure in a diabetic patient

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A previously healthy 48-year-old male developed diabetic ketoacidosis and severe hypophosphatemia. Within a few hours, acute respiratory insufficiency developed with a marked discrepancy between the pulmonary pathology and the very poor oxygenation seen. We argue that this was due to the effect of hypophosphatemia on respiratory muscle- and heart function and P50, leading to impaired oxygen delivery.

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Hasselstrøm, L., Wimberley, P.D. & Nielsen, V.G. Hypophosphatemia and acute respiratory failure in a diabetic patient. Intensive Care Med 12, 429–431 (1986). https://doi.org/10.1007/BF00254676

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Key words

  • Hypophosphatemia
  • Acute respiratory failure
  • Oxyhemoglobin dissociation curve