Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

  • Selected Papers of the 5th Congress of the European Society of Urological Oncology and Endocrinology, August 18–20, 1986, Edinburgh, UK
  • Published:

Carbohydrate residues in non-malignant prostatic epithelium as revealed by lectins


Non-neoplastic prostatic epithelium from 39 patients obtained at transurethral resection for outflow tract obstruction and 5 normal prostates from men under 35 years of age obtained at postmortem were formalinfixed and paraffin-embedded. The distribution of 8 lectin receptors were studied using a peroxidase anti-peroxidase method and an avidin-biotin method. Con A, WGA, and PNA bound to most epithelial cells. Con A,and WGA also showed major stromal binding. Approximately 5% to 10% of cells bound UEA1, GS1, DBA, and BPA. No major differences in lectin receptor expression were observed between normal and hyperplastic epithelium with either of the immunohistochemical techniques except that hyperplastic cells stained more strongly than normal epithelium.

This is a preview of subscription content, log in to check access.


  1. 1.

    Bischof W, Anmuller G (1982) Age dependent changes in the carbohydrate pattern of human epithelium as determined by peroxidase-labelled lectins. Prostate 3:507–513

  2. 2.

    Catalona WJ (1981) Practical utility of specific red-cell adherence test in bladder cancer. Urology 18:113–117

  3. 3.

    De Klerk DP (1983) The glycosaminoglycans of normal and hyperplastic prostate. Prostate 4:73–81

  4. 4.

    Feizi T (1985) Carbohydrate antigens in human cancer. Cancer Surv 4:245–269

  5. 5.

    Feizi T, Childs RA (1985) Carbohydrate structures of glycoproteins and glycolipids as differentiation antigens, tumour associated antigens and components of receptor systems. Trends Biochem Sci 10:24–29

  6. 6.

    Fujita J, Matsumoto K, Kishi K, Ishiyama I (1981) synthesis of ABH blood-group substances in bladder tumours. Br J Urol 53:448–452

  7. 7.

    Kay HEM, Wallace DM (1961) A and B antigens of tumours arising from urinary epithelium. J Natl Inst Cancer 26:1349–1365

  8. 8.

    Leathem A, Atkins N (1983) Lectin binding to formalin-fixed paraffin sections. J Clin Pathol 36:747–750

  9. 9.

    Leathem A, Atkins N (1983) Lectin binding to paraffin sections. In: Bullock GR, Petrusz P (eds) Techniques in immunocytochemistry, vol 2. Academic Press, London

  10. 10.

    Limas C, Lange P (1982) A, B, H detectability in normal and neoplastic urothelium. Influence of methodologic factors. Cancer 49:2476–2484

  11. 11.

    Stein BS, Kendall AR (1982) Blood-group antigens and bladder carcinoma: a perspective. Urology 20:229–233

  12. 12.

    Thorpe SJ, Abel P, Slavin G, Feizi T (1983) Blood group antigens in the normal and neoplastic bladder epithelium. J Clin Pathol 36:873–882

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Abel, P.D., Leathem, A., Aylott, A. et al. Carbohydrate residues in non-malignant prostatic epithelium as revealed by lectins. Urol. Res. 15, 173–176 (1987).

Download citation

Key words

  • Lectins
  • Carbohydrates
  • Non-malignant prostate