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  • Selected Papers of the 5th Congress of the European Society of Urological Oncology and Endocrinology, August 18–20, 1986, Edinburgh, UK
  • Published:

Aromatization of androstenedione to estrogen by benign prostatic hyperplasia, prostate cancer and expressed prostatic secretions

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  • 10 Citations

Summary

Human prostatic tissue and expressed prostatic secretions (EPS) efrom patients with benign prostatic hyperplasia (BPH) and prostate cancer were incubated with (1 β 3H) androstenedione. The extent of aromatization was determined by measuring the transfer of 3H from the 1 β position into water. The amount of 3H2O recovered corresponds to the estrogens formed. Tissue from 5 patients with BPH yielded 2.13 (±1.05) pmol/mg protein/h while the EPS from the same patients yielded 727 fmol/mg protein/h. In patients with prostate cancer the mean formation of estrogens was 388 fmol/mg protein/h (±75). 4-hydroxyandrostenedione, an aromatase inhibitor, successfully inhibited aromatization in BPH and prostate cancer 53–98%.

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Stone, N.N., Laudone, V.P., Fair, W.R. et al. Aromatization of androstenedione to estrogen by benign prostatic hyperplasia, prostate cancer and expressed prostatic secretions. Urol. Res. 15, 165–167 (1987). https://doi.org/10.1007/BF00254430

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Key words

  • Aromatization
  • BPH
  • Prostate cancer
  • Prostatic secretions