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The effect of glucose-dependent insulinotropic polypeptide infused at physiological concentrations on the release of insulin in man


Blood glucose and the responses of insulin and glucose-dependent insulinotropic polypeptide (GIP) were measured in 12 healthy, normal weight subjects after drinking 50g glucose. On a subsequent occasion each subject was given a simultaneous infusion of GIP and glucose to mimic the plasma concentrations observed in the first test. The peak GIP concentration after oral glucose was 22.3±1.9pmol/l (mean±SEM), but was higher after GIP infusion at 36.3±4.6pmol/l, (p<0.005). The blood glucose levels following oral glucose peaked at 6.3 ±0.5 mmol/l which'was the same as seen after intravenous glucose. The insulin response to oral glucose was, however, far higher (431.3±58.2pmol/l) than that obtained after GIP and glucose infusion (191.6 ±30.9 pmol/l, p<0.001). Thus it has not proved possible to explain completely the oral enhancement of insulin release by the action of GIP alone.


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Sarson, D.L., Wood, S.M., Holder, D. et al. The effect of glucose-dependent insulinotropic polypeptide infused at physiological concentrations on the release of insulin in man. Diabetologia 22, 33–36 (1982). https://doi.org/10.1007/BF00253866

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Key words

  • Glucose-dependent insulinotropic polypeptide
  • gastric inhibitory polypeptide (GIP)
  • insulin
  • blood glucose
  • enteroinsular axis
  • incretin