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Validity of rapid estimation of erythrocyte volume in the diagnosis of polycytemia vera

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Abstract

In the diagnosis of polycytemia vera, estimation of erythrocyte volume (EV) from plasma volume (PV) and venous hematocrit (Hct v ) is usually thought unadvisable, because the ratio of whole body hematocrit to venous hematocrit (f ratio) is higher in patients with splenomegaly than in normal subjects, and varies considerably between individuals. We determined the mean f ratio in 232 consecutive patients suspected of polycytemia vera (\(\bar f = {\text{0}}{\text{.967}}\);SD 0.048) and used it with each patient's PV and Hct v to calculate an estimated normalised EV n . With measured EV as a reference value, EV n was investigated as a diagnostic test. By means of two cut off levels the EV n values could be divided into EV n elevated, EV n not elevated (both with high predictive values), and an EV n borderline group. The size of the borderline EV n group ranged from 5% to 46% depending on position of the cut off levels, i.e. with the efficiency demanded from the diagnostic test. EV can safely and rapidly be estimated from PV and Hct v , if \(\bar f\) is determined from the relevant population, and if the results in an easily defineable borderline range of EV n values are supplemented by direct EV determination.

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References

  1. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet i:307–10

  2. Bowring CS (1981) The measurement of red cell volume and plasma volume. In: Bowring CS (ed) Radionuclide tracers in haematology. London, Butterworths, pp 31–43

  3. Davies JWL (1971) Blood volume studies. In: Beloher EH, Vetter H (eds) Radioisotopes in medical diagnoses. London, Butterworths, pp 319–41

  4. Fairbanks VF, Tauxe WN (1967) Plasma and erytrocyte volumes in obesity, polycytemia and related conditions. In: Bergner PE, Lushbaugh (eds) Compartments, pools and spaces in medical physiology. U.S. Atomic Energy Commission, Oak Ridge, Tennessee; pp 283–298

  5. Fudenberg H, Baldini M, Mahoney IP, Dameshek W (1961) The body hematocrit/venous hematorcrit ratio and the “splenic reservoir”. Blood 17:71–82

  6. International Committee for Standardization in Haematology (1973) Standard techniques for the measurement of red-cell and plasma volume. Br J Haematol 25:801–14

  7. Loria A, Sánchez-Medal L, Kauffer N, Quintanar E (1962) Relationship between body hematocrit and venous hematocrit in normal, splenomegalic, and anemic states. J Lab Clin Med 60:396–408

  8. Mollison PL (1973) Blood volume. In: Mollison PL (ed) Blood transfusion in clinical medicine. London, Blackwell, pp 99–129

  9. Najean Y, Cacchione R (1977) Blood volume in health and disease. Clin Haematol 6:543–66

  10. Tsan M, McIntyre PA (1983) Haematology In: Maisey MN, Britton KE, Gilday DL (eds) Clinical nuclear medicine. London, Chapman and Hall, pp 301–24

  11. Wright RR, Tono M, Pollycove M (1975) Blood volume. Semin Nucl Med 5:63–78

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Correspondence to Paul Rødbro.

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Nielsen, S., Rødbro, P. Validity of rapid estimation of erythrocyte volume in the diagnosis of polycytemia vera. Eur J Nucl Med 15, 32–37 (1989). https://doi.org/10.1007/BF00253596

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Key words

  • Erythrocyte volume
  • Polycytemia vera
  • Isotope dilution technique
  • Body/venous hematocrit ratio