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Regional distribution of ventilation and perfusion in patients with obstructive pulmonary disease and alpha1-antitrypsin deficiency


Regional distribution of pulmonary ventilation and perfusion has been determined of 13 patients with chronic obstructive pulmonary disease (COPD). Eight patients had alpha1-antitrypsin deficiency (α1ATD). Ventilation studies were carried out using xenon-133 (133Xe) and krypton-81m (81mKr) gases. Trapping indices were determined from the wash-out part of the xenon ventilation studies.

Results obtained from patients were compared with those of normal controls. Ventilation studies with 81mKr showed pulmonary changes more clearly than did 133Xe studies and the trapping of radio-xenon was more extensive in lung bases than in apices whether or not the patients had α1ATD. The distribution of perfusion followed a pattern similar to that of ventilation, but did not differ statistically from that of the normal controls.

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  1. Fallat R, Powell M, Kueppers F, Nadel J, Murray J (1971) Chronic obstructive pulmonary disease with intermediate alpha1-antitrypsin deficiency. Chest 59:20S-22S

  2. Fallat RJ, Powell MR, Kueppers F, Lilker E (1973) 133Xe ventilation studies in α1-antitrypsin deficiency. J Nucl Med 14:5–13

  3. Fremlin JH, Stammers K, Stewart FR (1978) A new generator for krypton-81m. Nucl Instrum Meth 156:369–373

  4. Heckscher T, Bass H, Oriol A, Rose B, Anthonisen NR, Bates DV (1968) Regional lung function in patients with broncial asthma. J Clin Invest 47:1063–1070

  5. Jones T, Clark JC, Hughes JM, Rosenzweig DY (1970) 81mKr generator and its uses in cardiopulmonary studies with scintillation camera. J Nucl Med 11:118–1243

  6. Kanner RE, Klauber MR, Watanabe S, Renzetti AD, Bigler A (1973) Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha1-antitrypsin. Am J Med 54:706–772

  7. Laurell CB, Eriksson S (1963) The electrophoretic alpha1-globulin pattern of serum in alpha1-antitrypsin deficiency. Scan J Clin Invest 15:132–149

  8. Mittman C, Lieberman J, Marasso F, Miranda A (1971) Smoking and chronic obstructive lung disease in alpha1-antitrypsin deficiency. Chest 60:214–221

  9. MRC (1965) Definition and classification of chronic bronchitis for clinical and epidemiological purposes. Lancet 1, 775

  10. Schor RA, Shames DM, Weber PM, Dos Remedios LV (1978) Regional ventilation studies with 81mKr and 133Xe: A comparative analysis. J Nucl Med 19:349–353

  11. Secker-Walker RH, Hill RI, Markham J, Baker J, Wilhelm J, Alderson PO, Potchen EJ (1973) The measurement of regional ventilation in man: A new method of quantitation. J Nucl Med 14:725–732

  12. Stevens PM, Hnilica VS, Johnson PC, Bell RL (1971) Pathophysiology of hereditary emphysema. Ann Intern Med 74:672–680

  13. Stockley RA (1979) Alpha1-antitrypsin phenotypes in cor pulmonale due to chronic obstructive airways disease. Q J Med 48:419–428

  14. Susskind H, Atkins HL, Goldman AG, Acevedo JC, Pate HR, Richards P, Brill AB (1981) Sensitivity of 81mKr and 127Xe in evaluating nonembolic pulmonary disease. J Nucl Med 22:781–786

  15. Welch MH, Richardson RH, Whitcomb WH, Hammarsten JF, Guenter CA (1969) The lung scan in alpha1-antitrypsin deficiency. J Nucl Med 10:687–690

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Correspondence to Abul B. M. G. Mostafa.

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Mostafa, A.B.M.G., Tulley, N.J., Harding, L.K. et al. Regional distribution of ventilation and perfusion in patients with obstructive pulmonary disease and alpha1-antitrypsin deficiency. Eur J Nucl Med 8, 338–341 (1983).

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  • Public Health
  • Chronic Obstructive Pulmonary Disease
  • Nuclear Medicine
  • Normal Control
  • Pulmonary Disease