Of 114 pyrophosphate (PPi) myocardial studies, eleven were selected to assess the significance of diffuse uptake observed in the images obtained early (2–3 h) following injection and compared with delayed scintigrams at 6–24 h. From the results of the late studies the patients were divided into two groups; those with no or minimal residual activity in the delayed study (five cases) and those with approximately the same intensity of delayed scans as in the early study (six cases). No significant abnormalities in cardiac enzymes or the EKG (obtained within 24 h) were noted in the patients of the first group. Cardiac enzymes, EKG abnormalities, indicating myocardial damage, or decreased radionuclide LVEF dysfunction were found in the patients of second group. We concluded that a late image is required in a case of diffuse PPi myocardial uptake in the early image, and myocardial damage may be present if there is persistently diffuse uptake of PPi in the late image.
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Bonte FJ, Parkey RW, Graham KD, Moore J, Stokely EM (1974) A new method for radionuclide imaging of myocardial infarcts. Radiology 110:473
Codini MA, Turner DA, Battle WE, Hassan P, Ali A, Messer JV (1979) Value and limitation of 99mTc pyrophosphate in detection of acute myocardial infarction. Am Heart J 98:752–762
Goldsmith SJ (1981) Radiopharmaceuticals in gamma images in benign and metabolic bone diseases (Ed. Sy, WM) Boca Ration, Florida, CRC Press, pp 46–47
Makler PT, Lederman S, Charles ND, Malmud LS, Warner H, Reilley JJ (1979) Myocardial infarct imaging with 99mTc pyrophosphate and Tc-methylene diphosphonate: Lack of correlation. Clin Nucl Med 4:89–90
Massie BM, Botvinick EH, Werner JA, Chatterjee K, Parmley WW (1979) Myocardial scintigraphy with 99mTc pyrophosphate: An insensitive test for nontransmural myocardial infarction. Am J Cardiol 43:186–192
Parkey RW, Bonte FJ, Meyer SL, Atkins JM, Curry GL, Stokely EM, Willerson JT (1974) A new method for radionuclide imaging of acute myocardial infarction in humans. Circulation 50:540
Schelbert HR, Wisenberg G, Ratib O. Nuclear Medicine (1981) A new tool in the diagnosis of cardiac disease. Current problems in diagnostic radiology 10:13
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Shih, W.-., DeLand, F.H., Domstad, P.A. et al. Sequential early and delayed myocardial 99mTc pyrophosphate scans: Evaluation of diffuse myocardial uptake. Eur J Nucl Med 8, 329–331 (1983). https://doi.org/10.1007/BF00253538
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