A radioisotopic method was used to evaluate the state and dynamics of the lymphatic system in 92 patients affected by chronic oedema of the limbs and in 12 control subjects. After interstitial injections of 99mTc-sulphur microcolloid, scans were obtained using a LFOV camera linked to a data processor. The quantitative indices of clearance and lymph node uptake obtained showed good correlation with lymphoedema etiology, controls and ostensibly healthy limbs of patients affected by monolateral disease. In conclusion, quantitative lymphoscintigraphy appears to be a feasible indicator of early changes in the lymph pathophysiology and supports the hypothesis that lymphoedema generally arises from a predisposing congenital pathology.
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Anghileri LJ (1967) Lymphonode distribution of several radiocolloids, migration ability through the tissue. J Nucl Med 11:180–183
Bergquist L, Stcard SE, Persson B, Hafotrom L, Jonsson PE (1982) Dosimetry in lymphoscintigraphy of Tc-99m Antimony Sulfide Colloid. J Nucl Med 23:698–705
Bergquist L, Stcard SE, Persson BRR (1983) Practicle sizing and biokinetics of interstizial lymphoscintigraphic agents. Sem Nucl Med Vol XIII, pp 9–19
Bronskill MJ (1983) Radiation dose estimates for interstitial radiocolloid lymphoscintigraphy. Sem Nucl Med Vol XIII, pp 20–25
Cox PH (1971) The preparation of mercuric sulphide suspension for lymphatic investigations and the influence of particle size on its physiological properties. Radioisotopy 12:997–999
Croll MN, Brady WL, Dad Parvar S (1983) Implications of lymphoscintigraphy in Oncologic Practice: principles and differences vis-a-vis other imaging modalities. Sem Nucl Med 13:4–8
Frühling J, Massant B, Verbist A (1983) Quantitative bipedal lymphoscintigraphy. J Nucl Med 24:40
Hollander M, Wolfe DA (1973) Non parametric statistical method. In: Wiley, New York, pp 114–119
Kaplan WD, Slavin SA, Markisz JA, Laffin SM, Royal HD (1983) Qualitative and quantitative upper extremity radionuclide lymphoscintigraphy. J Nucl Med 24:40
Ketterins C (1981) The distribution patterns of macromolecular in oedematons limbs. In: Cox PH (ed) Progress in radiopharmacology. Vol 2, Elsevier North-Holland Biomedical Press, Amsterdam, pp 305–315
Kinmonth JB (1954) Lymphoangiography in clinical surgery particularly in the treatment of lymphoedema. Ray Coll Engl 12:300–302
Pedersen B, Kristensen K (1981) Evaluation of methods for sizing of colloidal radiopharmaceuticals. Eur J Nucl Med 6:521–526
Sacks GA, Born ML, Clanton JA, Hunter WW, Franklin J, Rollo FO (1981) Practicable lymphoscintigraphy as an adjunct to micro-lymphatico-venous emastomoses. J Nucl Med 22:49
Sacks GA, Sandler MP, Born ML, Clanton JA, Franklin JD, Partain L (1983) Lymphoscintigraphys as an adjunctive procedure in the perioperative assessment of patients undergoing microlymphaticovenous enastomoses. Clin Nucl Med 8:309–311
Vaqueiro M, Gloviczki P, Fisher J, Holliey LH, Schirger A, Wahner HW (1986) Lymphoscintigraphy in lymphoedema: an aid to microsurgery. J Nucl Med 27:1125–1130
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Carena, M., Campini, R., Zelaschi, G. et al. Quantitative lymphoscintigraphy. Eur J Nucl Med 14, 88–92 (1988). https://doi.org/10.1007/BF00253447
- 99mTc-sulphur microcolloid
- Limb oedema