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European Journal of Nuclear Medicine

, Volume 7, Issue 7, pp 311–317 | Cite as

The hepatic excretion of 131I-rose bengal and 99mTc-IDA derivatives in Rotor's syndrome

  • G. Galli
  • C. Focacci
  • C. L. Maini
  • M. Salvatori
  • L. Troncone
  • G. L. Fedeli
  • G. L. Rapaccini
Article

Abstract

Bilirubin kinetics and hepatobiliary excretion of some exogenous anions (BSP, 131I-rose bengal, diethyl and parabutyl-IDA labeled with 99mTc) were studied in three patients presenting with Rotor's syndrome. Two were brothers; a nonjaundiced fraternal twin of one of them was also evaluated. The hepatic clearance of the radiopharmaceuticals was impaired in the affected patients but the degree of impairment was different among the tested anions, i.e., maximal for 99mTc-diethyl-IDA and minimal for 131I-rose bengal.

Parabutyl-IDA was cleared better than the diethyl derivative. The metabolic derangement seems to be at the level of transfer from plasma to liver and of the hepatic storage, rather than at the level of hepatocyte excretory pathways, as in the case of Dubin-Johnson syndrome.

Keywords

Public Health Bilirubin Nuclear Medicine Diethyl Hepatic Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. Galli
    • 1
  • C. Focacci
    • 1
  • C. L. Maini
    • 1
  • M. Salvatori
    • 1
  • L. Troncone
    • 1
  • G. L. Fedeli
    • 2
  • G. L. Rapaccini
    • 2
  1. 1.Istituto di Medicine NucleareUniversità Cattolica del Sacro CuoreRomaItaly
  2. 2.Instituto di Patologia MedicaUniversità Cattolica del Sacro CuoreRomaItaly

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