Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

A new apparatus for generating hygroscopic radioactive aerosols for inhalation studies

  • 31 Accesses

  • 5 Citations


Radioaerosols are being used increasingly to assess pulmonary ventilation in patients, and to study patterns distribution and rates of clearance in experimental studies. No completely satisfactory means have been developed to permit the safe and effective administration of suitable aerosols. In this report, a new system is described for producing and delivering monodisperse radioactive aerosol particles. The major advantages of the system are: (1) the monodispersion (σg=1.23) of the particles from modifier A; (2) 95% of the particles are less than 1 μm in diameter from modifier B, and (3) the method is simple and compact.

This is a preview of subscription content, log in to check access.


  1. Berglund RN, Liu BYH (1973) Generation of monodisperse aerosol standards. Environ Sci Technol 7:147–153

  2. Conner WD (1966) An inertial-type particle separator for collecting large sample. J Air Pollut Control Assoc 16:35–38

  3. Davis CN, Aylward M (1951) The trajectories of heavy, solid particles in a two-dimensional jet of ideal fluid impinging normally upon a plate. Proc Phys Soc B64:889–911

  4. Friedlander SK (1977) Smoke dust and haze, fundamentals of aerosol behavior. John Wiley and Sons, New York

  5. Fuchs NA (1964) The mechanics of aerosols, Pergamon Press, Oxford

  6. Jones JG, Minty BD, Lawler P, Hulands G, Crawley JCW, Feall N (1980) Increased alveolar epithelial permeability in cigarette smokers. Lancet 66–68

  7. Loo BW, Jaklevic JM, Goulding FS (1976) Dichotomous virtual impactors for large scale monitoring of airborne particulate matter. In: Liu BYH (ed) Fine Particles. Academic Press, New York. pp. 312

  8. Marple VA, Liu BYH (1974) Characteristics of laminar jet impactors. Environ Sci Technol 8:648–654

  9. Marple VA, Willeke K (1976) Impactor design. Atomos Environ 10:891–896

  10. Mason BJ (1957) The physics of clouds, University Press, Oxford, Oxford, pp. 24–34

  11. Masuda H, Hochrainer D, Stober W (1979) An improved virtual impactor for particle classification and generation of test aerosols with narrow size distributions. J Aerosol Sci 10:275–287

  12. McFarland AR, Ortiz CA, Bertch RW Jr (1978) Particle collection characteristics of a single-stage dichotamous sampler. 12:679–682

  13. Mercer TT (1963) On the calibration of cascade impactors. Ann Occup Hyg 6:1–14

  14. Mercer TT (1973) Aerosol technology in hazard evaluation. Academic Press, New York, pp. 197–202

  15. Mercer TT, Stafford RG (1969) Impactor from round jets. Ann Occup Hyg 12:41–48

  16. Mitchell RI, Pilcher JM (1959) Improved cascade impactor for measuring aerosol particle sizes in air pollutants, commercial aerosols, cigarette smoke. Ind Eng Chem 51:1039–1042

  17. Morrow PE (1974) Aerosol characterization and deposition. Am Rev Respir Dis 110:88–99

  18. Raabe OG (1976) The generation of aerosols of fine particles. In: Liu BYH (ed) Fine Particles Academic Press, New York, pp 60–110

  19. Strauss W (1976) Industrial gas cleaning, 2nd ed. Pergamon Press, Oxford, pp. 409–430

  20. Taplin GV, Poe ND, Greenberg A (1966) Lung scanning following radioaerosol inhalation. JNM 7:77–87

  21. Taplin GV, Chapra SK (1978) Inhalation lung imaging with radioactive aerosols and gases. In: Guter M (ed), Progress in Nuclear Medicine. S. Karger Basel, pp. 119–43

  22. Willeke K, McFeters JJ (1975) The influence of flow entry and collecting surface on the impaction efficienty of inertial impactors. J Colloid Interface Sci 53:121–127

Download references

Author information

Correspondence to D. L. Swift.

Additional information

This work was supported in part by grants from the National Institutes of Health (Nos. GM 10548 and HL 19715)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Suzuki, T., Swift, D.L., Wagner, H.N. et al. A new apparatus for generating hygroscopic radioactive aerosols for inhalation studies. Eur J Nucl Med 7, 474–479 (1982).

Download citation


  • Public Health
  • Experimental Study
  • Pattern Distribution
  • Nuclear Medicine
  • Aerosol Particle