Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Relative cardiotoxicity and cytotoxicity of anthraquinonyl glucosaminosides

  • 22 Accesses

  • 1 Citations

Summary

The cardiotoxicity and cytotoxicity for tumor cells of four new synthetic anthraquinonyl glucosaminosides were compared in vitro. The nonhydroxylated anthraquinone was not cardiotoxic, and its cytotoxic activity was the weakest of the compounds in the series. Increasing the number of hydroxyl groups on the anthraquinone moiety increased the inhibition of growth of L-1210 leukemia cells and pancreatic or colonic adenocarcinomas in a soft agar colony formation assay. However, cardiotoxicity was also increased in proportion to the number of hydroxyl groups present. The adenocarcinomas were slightly more sensitive than the leukemias to the inhibitory action of the dihydroxylated anthraquinonyl glucosaminosides on cell growth.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Abramowicz M (1985) Cancer chemotherapy. Med Lett 27: 13

  2. 2.

    Abramson HN, Banning JW, Nachtman JP, Roginski ET, Sardessai M, Wormser HC, Wu J, Nagia Z, Schroeder R, Bernardo M (1986) Synthesis of anthraquinonyl glucosaminosides and studies on the influence of aglycone hydroxyl substitution on superoxide generation, DNA binding, and antimicrobial properties. J Med Chem 29: 1709

  3. 3.

    Bristow MR, Thompson PD, Martin RP, Mason JW, Billingham ME, Harrison DC (1978) Early anthracycline cardiotoxicity. Am J Med 65: 823

  4. 4.

    Casazza A (1979) Experimental evaluation of anthracycline analogs. Cancer Treat Rep 63: 835

  5. 5.

    Corbett TH (1984) A selective soft agar assay for drug discovery. Proc Am Assoc Cancer Res 25: 325

  6. 6.

    Corbett TH (1985) A selective soft agar assay for drug discovery. Proc Am Assoc Cancer Res 26: 332

  7. 7.

    Corbett TH, Wozniak A, Gerpheide S, Hanka L (1985) A selective two-tumor soft agar assay for drug discovery. In vitro and in vivo models for detection of new antitumor drugs. In: Hanka L, Kondo T, White R (eds) Fourteenth International Congress of Chemotherapy, Kyoto, 1985. University of Tokyo Press, Tokyo, pp 5–14

  8. 8.

    Corbett TH, Bissery M, Wozniak A, Plowman J, Polin L, Tapazoglou E, Dieckman J, Valeriote F (1986) Activity of flavone acetic acid (NSC 347512) against solid tumors of mice. Invest New Drugs 4: 207

  9. 9.

    Czarnecki CM (1984) Animal models of drug-induced cardiomyopathy. Comp Biochem Pharmacol 79C: 9

  10. 10.

    Doroshow H (1983) Effect of anthracycline antibiotics on oxygen radical formation in rat heart. Cancer Res 43: 460

  11. 11.

    Henry D (1976) Adriamycin. In: Sartorelli A (ed) Cancer Chemotherapy. American Chemical Society, Washington, p 15

  12. 12.

    Hill BT, Dennis LY, Li XT, Whelan RDJ (1985) Identification of anthracycline analogues with enhanced cytotoxicity and lack of cross-resistance to adriamycin using a series of mammalian cell lines in vitro. Cancer Chemother Pharmacol 14: 194

  13. 13.

    Lown JW (1983) The mechanism of action of quinone antibiotics. Mol Cell Biochem 55: 17

  14. 14.

    Lown JW, Chen HH, Plambeck JA, Acton EM (1979) Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents. Biochem Pharmacol 28: 2563

  15. 15.

    Perkins WE, Schroeder RL, Carrano RA, Imondi AR (1982) Effect of ICRF-187 on doxorubicin-induced myocardial effects in the mouse and guinea pig. Br J Cancer 46: 662

  16. 16.

    Perkins WE, Schroeder RL, Carrano RA, Imondi AR (1984) Myocardial effects of mitoxantrone and doxorubicin in the mouse and guinea pig. Cancer Treat Rep 68: 841

  17. 17.

    Singal P, Panagia V (1984) Direct effects of adriamycin on the rat heart sarcolemma. Res Commun Chem Pathol Pharmacol 43: 67

  18. 18.

    Tallarida RJ, Murray RB (1981) Manual of pharmacologic calculations with computer programs. Springer, New York, pp 150

Download references

Author information

Correspondence to Jon W. Banning.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Banning, J.W., Abramson, H.N., Wormser, H.C. et al. Relative cardiotoxicity and cytotoxicity of anthraquinonyl glucosaminosides. Cancer Chemother. Pharmacol. 19, 207–212 (1987). https://doi.org/10.1007/BF00252974

Download citation

Keywords

  • Tumor Cell
  • Agar
  • Leukemia
  • Adenocarcinoma
  • Inhibitory Action