Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

99mTc-HIDA dynamic scintigraphy for the diagnosis of gastroesophageal reflux of bile

  • 25 Accesses


In 5 patients with partial gastric resection and esophagitis, in whom esophageal pH metry was unable to demonstrate significant gastroesophageal reflux (GER), we administered i.v. 5 mCi (185 MBq) of 99mTc-HIDA, the patient lying under a computer-assisted LFOV gamma camera. When gallbladder image was evident, caerulein was administered i.v. at a physiologic dose in order to induce gallbladder contraction, and in the subsequent 45 min the patient was asked to perform a standard series of manoeuvres that increase the intraabdominal pressure (Valsalva, etc.) and favour GER. Scintigraphic images and time/activity curves obtained from areas of interest corresponding to gastric remnant and distal esophagus showed that at least one of these manoeuvres in each case was followed by the appearance of the radiocompound in the distal esophagus, indicating a 99mTc-HIDA-tagged bile GER. Consequently, we believe that HIDA-GER dynamic scintigraphy may be more useful than esophageal pH metry in demonstrating the biliary origin of an esophagitis.

This is a preview of subscription content, log in to check access.


  1. De Meester TR, Wang CI, Wenly SA, Pellegrini CA, Little AG, Klementschitsh P, Bermudez G, Johnson LF, Skinner DB (1980) Technique indications and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg 79:656–670

  2. Fisher RS, Malmud LS, Robert GS, Lobis IF (1976) Gastroesophageal (GE) scintiscanning to detect and quantitative GE reflux. Gastroenterology 70:301–308

  3. Tolin RD, Malmud LS, Stelzer F, Menin R, Makler PT Jr, Applegate G, Fisher RS (1979) Enterogastric reflux in normal subjects and in patients with Billroth II gastroenterostomy. Measurement of enterogastric reflux. Gastroenterology 77:1027–1033

Download references

Author information

Correspondence to Dr. M. Bortolotti.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bortolotti, M., Abbati, A., Turba, E. et al. 99mTc-HIDA dynamic scintigraphy for the diagnosis of gastroesophageal reflux of bile. Eur J Nucl Med 10, 549–550 (1985).

Download citation

Key words

  • Bile reflux
  • HIDA 99mTc hepatobiliary scintigraphy
  • Gastroesophageal reflux