Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Preliminary biodistribution studies with a hybrid positron scanner

Abstract

The hybrid positron scanner is a scanning device for imaging with short-lived positron-emitting radioisotopes. It is especially suitable for total body scanning studies. The scanner consists of two moveable parallel detectors, which are NaI(Tl)-crystals 40 cm long and 5 cm in diameter with a photomultiplier at each end. One detector is above and the other below the patient. The coordinate in the direction perpendicular to the crystal axis is determined from mechanical movement of the detectors. The coordinate along the crystal axis is determined from the signals of the photomultipliers.

The specifications of the hybrid positron scanner are presented. Biodistribution studies in rabbits on the accumulation of 18F in the skeleton and on the 13NH3 distribution in various organs are described. The regional pharmacokinetics of 11C-ethanol in man after peroral administration of the tracer is presented.

This is a preview of subscription content, log in to check access.

References

  1. Charkes N, Makler P, Philips C (1978) Studies of skeletal tracer kinetics. J Nucl Med 19:1301–1309

  2. Cooper A, McDonald J, Gelbard A, Gledhill R, Duffy T (1979) The metabolic fate of 13N-labelled ammonia in rat brain. J Biol Chem 254:4982–4992

  3. Davis T, Martone R (1966) The hybrid radioisotope scanner. J Nucl Med 7:114–127

  4. Grawley J, Veall N (1973) The design and some clinical applications of a hybrid positron scanner. In: Medical radioisotope scintigraphy 1972, Proceedings of a Symposium, Monte Carlo, vol 1. IAEA, Vienna, pp 105–112

  5. Keinänen M, Kuikka J (1980) Model analysis of transcapillary exchange: The role of cyclotron produced isotopes in the study of the capillary permeability of substances. Med Biol 58:128–139

  6. Keinänen M, Kuikka J, Heselius S-J, Suolinna E-M, Solin O, Långström B, Näntö V (1980) Transcapillary exchange and distribution of carbon-11 labelled ethanol in the isolated perfused liver. Acta Physiol Scand 110:39–46

  7. Kuikka J, Keinänen M, Solin O, Heselius S-J, Nantö V (1980) Liver sinusoidal permeability to ethanol and xenon molecules. In: Blood flow — theory and practice. London University, London, March 27–28

  8. Kulmala J, Markkula A, Keinänen M (1980) Preliminary experiments with a hybrid positron scanner. The second symposium on the medical application of cyclotrons, Proceedings of a Symposium, Turku, June 2–5, 1980

  9. Lockwood A, McDonald J, Reiman R, Gelbard A, Laughlin J, Duffy T, Plum F (1979) The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest 63:449–460

  10. Raichle M, Eichling J, Straatman M, Welch M, Larson K, TerPogossian M (1976) Blood-brain barrier permeability of 11C-labelled alcohols and 15O-labelled water. Am J Physiol 230:543–552

  11. Vauramo E, Virjo A (1977) The design of detector and collimator for a hybrid scanner. Br J Radiol 50:808–813

  12. Walsh W, Fill H, Harper P (1977) Nitrogen-13-labelled ammonia for myocardial imaging. Semin Nucl Med 7:59–66

  13. Wootton R (1974) The single-passage extraction of 18F in rabbit bone. Clin Sci Mol Med 47:73–77

Download references

Author information

Correspondence to Dr. Jarmo Kulmala.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kulmala, J., Keinänen, M., Markkula, A. et al. Preliminary biodistribution studies with a hybrid positron scanner. Eur J Nucl Med 6, 561–565 (1981). https://doi.org/10.1007/BF00252670

Download citation

Keywords

  • Public Health
  • Nuclear Medicine
  • Biodistribution Study
  • Mechanical Movement
  • Crystal Axis