Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Measurement of glomerular filtration rate with 99mTc-DTPA: A comparison of gamma camera methods

  • 53 Accesses

  • 9 Citations

Abstract

A comparison has been made between three gamma camera methods for estimation of glomerular filtration rate (GFR) using 99mTc-DTPA in a group of 27 patients with widely different renal function. Plasma clearance of 99mTc-DTPA by multiple blood sampling was used as the reference. Percentage uptake of chelate in the bladder and kidneys at 20 min after injection gave the lowest standard error of 8.0 ml/min. Techniques using early uptake of isotope in the kidneys at 2 min after injection gave less accurate estimates. Correction for the vascular activity in the renal region of interest improved the results for the 2 min uptake technique. Gamma camera techniques provide rapid estimates of GFR which are less accurate than those obtained by plasma clearance of labelled chelate.

This is a preview of subscription content, log in to check access.

References

  1. Corrigan DM, Collis SA (1984) Estimation of glomerular filtration rate, without blood samples, during renography. Clin Phys Physiol Meas 5:279–284

  2. Diffey BL, Hall FM, Corfield JR (1976) The 99mTc-DTPA dynamic renal scan with deconvolution analysis. J Nucl Med 17:352–355

  3. Fleming JS (1977) Measurement of hippuran plasma clearance using gamma camera. Phys Med Biol 22:526–530

  4. Fleming JS (1979) A technique for the absolute measurement of activity using a gamma camera and computer. Phys Med Biol 24:176–180

  5. Fleming JS, Goddard BA (1974) A technique for the deconvolution of the renogram. Phys Med Biol 19:546–549

  6. Gates GF (1982) Glomerular filtration rate: Estimation from fractional renal accumulation of 99mTc-DTPA (stannous). Am J Roentgenol 138:565–570

  7. Kampmann JP, Molholm Hanssen J (1981) Glomerular filtration rate and creatinine clearance. Br J Clin Pharmacol 12:7–14

  8. Kenny RW, Ackery DM, Fleming JS, Goddard BA, Grant RW (1975) Deconvolution analysis of the seintillation camera renogram. Br J Radiol 48:481–486

  9. Lee TY, Constable AR, Cranage RW (1982) A method for GFR determination without blood samples in routine dynamic 99mTc-DTPA renal imaging. In: Joekes AM, Costable AR, Brown NJG, Tauxe WN (eds) Radionuclides in Nephrology. Academic Press, London, pp 107–122

  10. Piepsz A, Denis R, Ham HR, Dobbeleir A, Schulman C, Erbsmann F (1978) A simple method for measuring separate glomerular filtration rate using a single injection of 99mTc-DTPA and the scintillation camera. J Paediatr 92:769–774

  11. Russell CD, Bischoff PG, Kontzen F, Rowell KL, Yester MV, Lloyd LK, Tauxe WN, Dubovsky EV (1987) Measurement of glomerular filtration of methods. Eur J Nucl Med 10:519–521

  12. Waller DG, Keast CM, Fleming JS, Ackery DM (1987) Measurement of glomerular filtration rate with 99mTc-DTPA: Comparison of plasma clearance techniques. J Nucl Med 28:372–377

Download references

Author information

Correspondence to Derek G. Waller.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Fleming, J.S., Keast, C.M., Waller, D.G. et al. Measurement of glomerular filtration rate with 99mTc-DTPA: A comparison of gamma camera methods. Eur J Nucl Med 13, 250–253 (1987). https://doi.org/10.1007/BF00252602

Download citation

Key words

  • Glomerular filtration rate
  • Kidney function
  • Isotope