The tissue distribution of a number of 5-[131I]-iodo-2-thiouracil derivatives was measured in Syrian golden hamsters with Greene melanoma. These compounds were rapidly (in less than 1 h) distributed in all tissues, while in most tissues fast elimination (T1/2 1–3 h) was observed. Because of retention of the 131I activity in the tumour, high tumour/non-tumour tissue ratios were found (e.g. tumour/eye 2.3–10, tumour/skin 1.5–3) suggesting that some of these compounds might be used as melanoma delineating agents, when labelled with 123I.
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van Langevelde, A., Bakker, C.N.M., Broxterman, H.J. et al. Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives. Eur J Nucl Med 8, 45–51 (1983). https://doi.org/10.1007/BF00252555
- Public Health
- Nuclear Medicine
- Tissue Distribution
- Golden Hamster