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Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus

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The effect of insulin in vitro on the fluidity of the human erythrocyte membrane in Type I (insulin-dependent) diabetic patients and healthy control subjects was investigated using a fluorescence technique. It was found that the addition of 10-9 mol/l porcine insulin significantly increased fluorescent probe lateral mobility in the membrane lipid layer but did not appear to produce any conformational changes of membrane proteins.


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Bryszewska, M., Leyko, W. Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus. Diabetologia 24, 311–313 (1983).

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Key words

  • Insulin
  • erythrocyte membrane
  • lateral mobility
  • Type I diabetes