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The comparison of 8-hydroxyquinoline, tropolone, and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with indium-111: A functional study

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Abstract

Tropolone forms a lipophilic complex with indium-111 which is capable of mediating the labelling of polymorphonuclear leucocytes (PMNs) by this isotope; labelling efficiencies are comparable with the best achieved using 8-hydroxyquinoline and acetylacetone. However, in terms of PMN chemotaxis and phagocytosis, tropolone is significantly less toxic than either of the other ligands. 8-Hydroxyquinoline was found to reduce PMN chemotaxis and phagocytosis to approximately 70% of the control values at a concentration of 20 μM. Tropolone may prove a superior labelling reagent.

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Correspondence to Paul Wyeth.

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Burke, J.E.T., Roath, S., Ackery, D. et al. The comparison of 8-hydroxyquinoline, tropolone, and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with indium-111: A functional study. Eur J Nucl Med 7, 73–76 (1982). https://doi.org/10.1007/BF00251647

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Keywords

  • Public Health
  • Nuclear Medicine
  • Functional Study
  • Acetylacetone
  • Labelling Efficiency