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Primary structure and mitogenic and angiogenic activities of brain-derived acidic fibroblast growth factor

Abstract

Pure brain-derived acidic fibroblast growth factor (aFGF) is a protein that is mitogenic for a variety of types of cells in culture, including vascular endothelial cells, and is angiogenic in vivo. The complete amino acid sequence of the 140-residue bovine aFGF has been determined and recognized to be homologous to basic fibroblast growth factor and both interleukin-1α and-1β. These four growth factors define a new class of homologous proteins that presumably diverged from a common ancestor.

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This article was presented during the proceedings of the International Conference on Macromolecular Structure and Function, held at the National Defence Medical College, Tokorozawa, Japan, December 1985.

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Thomas, K.A., Gimenez-Gallego, G., Rios-Candelore, M. et al. Primary structure and mitogenic and angiogenic activities of brain-derived acidic fibroblast growth factor. J Protein Chem 6, 163–171 (1987). https://doi.org/10.1007/BF00247764

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Key words

  • protein sequence
  • homology
  • lymphokines
  • neuropeptides