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Die Erregbarkeit des Halsganglion der Ratte durch Pharmaka

  • Hans Kaller
Article

Summary

Normally the superior cervical ganglion of the rat is not stimulated by acetylcholine, tetramethylammonium (TMA), dimethylphenylpiperazine (DMPP), nicotine, KCl and veratrine. If administered in sufficiently high doses the ganglionic transmission is blocked. The failure of excitations by drugs is supposed to be caused by a relatively high rate of accomodation in the ganglion of the rat. — After preadministration of eserine or neostigmine it is possible to stimulate the ganglion by acetylcholine. The preadministration however has no influence on the excitability of the ganglion cells to other depolarizing drugs. — Hexamethonium non-specifically raises the excitability to chemical stimulants.

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Literatur

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Copyright information

© Springer-Verlag 1956

Authors and Affiliations

  • Hans Kaller
    • 1
  1. 1.Aus der Pharmakologischen Abteilung der Medizinischen Forschungsanstalt der Max-Planck-GesellschaftGöttingen

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